Core--Transgenesis

这一核心有两个主要目标或目的，对所有四个项目和计划本身的成功至关重要。这两个主要目标是获得和维持程序化使用所需的已建立的小鼠系，为分析冠状动脉发育的病毒载体的产生、繁殖和分布提供便利。该核心还将提供核心B，即形态和成像核心，用于免疫化学分析，以生成我们的“正在发展的冠状动脉系统中的基因表达指数”。范德比尔特大学和康奈尔大学的核心建筑有两个组成部分。这一安排利用了已经到位的专业知识、设施和设备，并消除了人员、培训和后勤方面的重大变化。这一核心对于维持本方案所有四个项目的综合性质至关重要，并提供最有效和最具成本效益的资源使用。

This Core has two major goals or aims that are essential for the success of all four Projects and the Program itself. These two major goals are to obtain and maintain established mouse lines that are needed for the progress of Programmatic use, to provide a facility for the generation, propagation and distribution of viral vectors for analysis of coronary vessel development. The Core will also provide Core B, the Morphology and Imaging Core, materials for immunochemical analysis in the generation of our "Index of Gene Expression in the Developing Coronary System." There are two components of the Core housed at Vanderbilt and Cornell Universities. This arrangement takes advantage of the expertise, facilities and equipment already in place and negates major changes in personal, training and logistics. This Core is essential for the maintaining the integrated nature of all four Projects of the Program and provides the most efficient and cost effective use of resources.