Understanding Skin Permeation of Agrochemicals using Mass Spectrometry Imaging

已建立的评估皮肤渗透的方法仅提供了对通过皮肤的总体递送的了解，诺丁汉大学最近进行的工作已经证明，成像质谱技术可以对此进行详细说明，以更好地理解活性剂在皮肤组织内的递送并证明其定位。该项目旨在利用这些技术来进一步了解通过皮肤突出渗透途径和传递机制吸收农业化学成分。该项目的研究结果将使先正达的产品开发成为可能，并最终降低农用化学品使用者的暴露风险。申请人将在诺丁汉大学的一个已建立的皮肤渗透小组内工作，该小组利用独特的最先进设施，如3D OrbiSIMS（网址：//www.nottingham.ac.uk/nmrc/facilities/orbisims/orbitrap-sims.aspx)以提供以前无法获得的对农用化学品渗透到皮肤中以及它们对彼此渗透的渗透性的影响的了解特色

Established methodologies of assessing skin permeation only provide an insight into overall delivery through skin, more recent work undertaken at The University of Nottingham has demonstrated that imaging mass spectrometry techniques can elaborate on this to better understand the delivery of active agents within skin tissue and demonstrate their localisation. This project aims to utilise these techniques to further the understanding of the uptake of agrochemical components through skin highlighting routes of permeation and mechanisms of delivery. The findings from this project will enable product development at Syngenta and ultimately reduce the risks of exposure to agrochemical users.The applicant will work within an established skin permeation group at the University of Nottingham utilising unique state of the art facilities such as the 3D OrbiSIMS (https://www.nottingham.ac.uk/nmrc/facilities/orbisims/orbitrap-sims.aspx) to provide previously unavailable insight into the permeation of agrochemicals into skin as well as their impact upon the permeability of each other's permeation characteristics.