MRes in Medical Mycology and Fungal Immunology

耳念珠菌的表型适应性是否使其成为一种多重耐药的人类病原体？总结：我们将研究如何适应新兴的多药耐药真菌病原体，耳念珠菌，生理相关的环境压力驱动抗真菌药物耐药性和形状与主机的相互作用。这种真菌的临床分离株在几个细胞特征方面变化很大，如细胞壁特征和抗真菌药物的敏感性。我们将阐明如何细胞壁动力学，抗真菌耐药性和宿主-病原体相互作用的增强，作为C。耳适应通常在宿主龛中遇到的压力。

Does the phenotypic adaptability of Candida auris enable its success as a multi-drug resistant human pathogen?Summary: We will study how adaptation of the emerging multi-drug resistant fungal pathogen, Candida auris, to physiologically relevant environmental stresses drives antifungal drug resistance and shapes its interaction with the host. Clinical isolates of this fungus are highly variable with respect to several cellular traits, such as cell wall features and sensitivity to antifungal drugs. We will elucidate how cell wall dynamics, antifungal resistance and host-pathogen interactions are enhanced as C. auris adapts to stresses commonly encountered in host niches.