Emory Alcohol and Lung Biology Center

修订摘要 埃默里大学的酒精研究小组已经确定， 酒精滥用会增加3倍的风险发展急性 呼吸窘迫综合征（ARDS）是一种严重的肺损伤， 每年都有成千上万的美国人死于这种疾病 事实上，该中心 近600例患者的研究表明， 患有ARDS的患者有严重的酗酒史。 此外，本发明还提供了一种方法， 该中心的调查人员已经确定，乙醇介导的 关键的抗氧化剂谷胱甘肽的消耗产生特定的 肺结构和功能缺陷，使肺易受 急性损伤。 ARDS是一系列组织损伤的一部分， 重症患者被称为“多器官 功能障碍综合征。 这种综合症会产生毁灭性的后果 死亡率和存活者长期发病率。 然而，在这方面， 它不会重新出现，而是对各种急性 例如创伤和败血症。 重要的问题是 酗酒使肺和其他器官容易受伤， 重症患者的失败？ 中心调查员 假设酒精滥用会导致慢性氧化应激， 肺，以及一系列随之而来的肺结构缺陷， 功能使患者易患呼吸衰竭， 相关的多器官功能障碍 此外，该机制影响 母亲严重酗酒而早产的婴儿 除了成人入住重症监护室外， 治疗败血症、创伤或其他严重疾病。 拟议 埃默里酒精和肺生物学中心将扩展以前的工作， 剖析临床关联以及基本机制 潜在的酗酒和多器官功能障碍 资本化 在建立合作以及人才的最近 招聘教师，该中心将测试中心的假设， 包括体外和体内的一整套相关项目 动物模型，以及儿科和成人的临床研究 重症监护病房 中心将开展六项合作 研究酒精对肺部影响的项目 上皮、内皮和基质生物学。 与此同时，飞行员 该部分将促进新的试点项目， 酒精介导的组织损伤的基础和临床方面 项目 最后，该中心将培养科学家， 酒精研究的职业 本中心提出的工作建议 对诊断的理解有着巨大的影响， 重症监护室中数十万患者的预后 在整个美国，并可能导致小说的发展 多器官功能障碍风险最大的患者的治疗 长期酗酒导致的机能障碍

REVISED ABSTRACT The alcohol research group at Emory University has determined that alcohol abuse increases the risk 3-fold of developing the Acute Respiratory Distress Syndrome (ARDS), a severe form of lung injury that kills tens of thousands of Americans each year. In fact, the Center's studies in nearly 600 patients indicate that ~50% of all patients who develop ARDS have a significant history of alcohol abuse. In addition, the Center's investigators have determined that ethanol-mediated depletion of the critical antioxidant glutathione produces specific defects in lung structure and function that render the lung susceptible to acute injury. ARDS is part of a spectrum of tissue injury in critically ill patients that has been termed the 'multiple organ dysfunction syndrome'. This syndrome produces devastating consequences in terms of mortality and prolonged morbidities in survivors. However, it does not arise de novo but rather in response to a variety of acute insults, such as trauma and sepsis. The important question is how does alcohol abuse render the lung and other organs susceptible to injury and failure in critically ill patients? The Center investigators hypothesize that alcohol abuse produces chronic oxidative stress within the lung, and that an array of consequent defects in lung structure and function render patients susceptible to respiratory failure and associated multiple organ dysfunction. Further, this mechanism affects infants born prematurely to mothers with a significant alcohol abuse history in addition to adults admitted to intensive care units for treatment of sepsis, trauma, or other critical illnesses. The proposed Emory Alcohol and Lung Biology Center will extend this previous work and dissect the clinical associations as well as the fundamental mechanisms underlying alcohol abuse and multiple organ dysfunction. Capitalizing on established collaborations as well as the talents of recently recruited faculty, the Center will test the central hypothesis in a comprehensive set of related projects that include in vitro and in vivo animal models, as well as clinical studies in pediatric and adult intensive care unit settings. The Center will conduct six collaborative research projects that examine the effects of ethanol on lung epithelial, endothelial, and matrix biology. In parallel, the Pilot Component will facilitate novel pilot projects that will identify new aspects of alcohol-mediated tissue injury in basic and clinical projects. Finally, the Center will nurture the training of scientists for careers in alcohol research. The work proposed by this Center has enormous implications for the understanding of the diagnosis and prognosis of hundreds of thousands of patients in intensive care units throughout the U.S., and could lead to the development of novel therapies for those patients at greatest risk for multiple organ dysfunction as a consequence of chronic alcohol abuse.