Integrated Technology Resource for Polymeric Biomaterials

描述（由申请人提供）：在理解细胞生物学、伤口愈合和靶向药物作用方面的持续进展正在以前所未有的方式为可降解、生物相容性聚合物的使用创造机会。高分子生物材料资源（RESBIO）将通过综合技术为生物医学界提供先进的材料科学服务，包括a)合成和加工，b)微纳米级结构测定，以及3)材料及其与细胞相互作用的表征。利用这些技术之间的关系来最终控制细胞反应是推进生物材料临床应用的有力途径；这是RESBIO的核心战略。一个独特的资源集群将由新泽西州生物材料中心创建和托管，这是一个由新泽西州一流高等教育机构组成的蓬勃发展的学术联盟。该资源将侧重于聚合物生物材料的合成、生产规模扩大到公斤级、加工和使用材料科学、工程和分子生物学技术的大块材料特性的表征。RESBIO将与ncrr资助的国家ESCA和生物医学问题表面分析中心（NESAC/BIO）密切互动和补充。核心技术研发项目将集中于聚合物设计的组合和计算方法，高通量和生物相关表征，散装生物材料微纳米结构分析，以及原位细胞分析。合作将涉及基本的生化/生物材料研究和医疗设备的开发，如韧带置换和血管移植。RESBIO实验室将提供综合服务，涵盖平行聚合物合成、聚合物加工、电子能量损失光谱和多光子共聚焦显微镜。传播活动将包括学术出版物、专业发展短期课程和讲习班、会议和海报展示，以及一个综合网站。广泛的培训计划将包括美国国立卫生研究院资助的培训计划和研究生课程的博士后实习。

DESCRIPTION (provided by applicant): Ongoing advances in understanding cell biology, wound healing and targeted drug effects are creating opportunities for the use of degradable, biocompatible polymers in unprecedented ways. The Resource for Polymeric Biomaterials, RESBIO, will bring advanced materials science to the service of the biomedical community through integrated technologies for a) synthesis and processing, b) micro- and nanoscale structure determination, and 3) characterization of both materials and their interactions with cells. Taking advantage of the relationships among these technologies for the ultimate control of cellular responses is a powerful approach to advancing clinical applications of biomaterials; this is the central strategy of RESBIO. A distinctive resource cluster will be created and hosted by the New Jersey Center for Biomaterials, a thriving academic consortium of New Jersey's premier institutions of higher education. This resource will focus on the synthesis of polymer biomaterials, scale-up of production to kilogram levels, processing, and characterization of bulk material properties using the techniques of materials science, engineering, and molecular biology. RESBIO will interact closely with and complement the NCRR-funded National ESCA and Surface Analysis Center for Biomedical Problems (NESAC/BIO). Core technological R&D projects will focus on combinatorial and computational approaches to polymer design, high-throughput and biorelevant characterization, profiling bulk biomaterial micro- and nanostructure, and in situ cell profiling. Collaborations will involve both basic biochemical/biomaterials research and the development of medical devices such as ligament replacements and vascular grafts. RESBIO laboratories will provide integrated services spanning parallel polymer synthesis, polymer processing, electron energy loss spectroscopy, and multiphoton confocal microscopy. Dissemination activities will feature scholarly publications, professional development short courses and workshops, conference and poster presentations, and a comprehensive website. A broad training program will include postdoctoral residencies in an NIH-funded training program and graduate courses.