BONE MINERAL DENSITY AS A PREDICTOR OF PERIODONTITIS

描述(申请人提供)：本研究的总体目的是 确定口腔和全身骨密度(BMD)在 绝经后妇女新的进行性牙周病的发展。 我们假设低骨密度与新发和进展性骨密度有关。 随着时间的推移，牙周炎对破坏性疾病的易感性增加 牙周炎。我们建议对骨密度进行纵向评估及其在 系统性牙周病在绝经后妇女中的建立 使用敏感和准确的骨骼和口腔骨密度测量方法的研究，以及 牙周病。作为BMD评估的一部分，我们将进一步验证 口腔骨密度测定的方法学。与此相一致的是，对各种 低骨密度和牙周炎的潜在共同危险因素将使我们能够 确定他们对该协会的贡献。系统协变量 包括年龄、体重指数、吸烟、酒精、激素使用、社会经济和 心理社会因素、药物、病史和生育史，以及饮食。 局部协变量包括菌斑、牙周炎、探诊深度、既往牙病史 护理和牙齿护理习惯。研究对象将从 已建立的绝经后妇女队列，基线评估BMD和 牙周炎是正在进行的横断面研究的一部分。我们提出了一个三维亚尔 美国国立卫生研究院1000名绝经后妇女的随访检查 妇女健康倡议研究。到目前为止，研究还没有表征 骨骼或下颌骨骨密度在牙周病中的特殊作用 在一大群绝经后妇女中的发病率和进展。我们的 初步横断面研究已经确定骨骼骨密度是 与牙槽突高度、牙齿脱落和临床依恋有关 损失。拟议的纵向研究将有足够的样本量和 评估BMD和BMD之间的时间关系的统计能力 牙周炎与一大组共同危险因素和潜在因素的影响 影响骨量减少和/或牙周病的混杂因素。这 研究提供了在成本中定义这种关系的独特机会 作为研究的一部分，一组绝经后妇女的有效方式 妇女健康倡议具有重大的现实意义。低骨密度是 可能在疾病的发生和发展中起着相当重要的作用 牙周炎。因此，一旦建立了关系，模式就有效 在预防和治疗骨质疏松症方面可能被证明是有用的 以及牙周炎和随后的牙齿脱落的治疗。

DESCRIPTION (provided by applicant): The overall purpose of this study is to determine the role of oral and systemic bone mineral density (BMD) in the development of new and progressive periodontal disease in postmenopausal women. We hypothesize that low BMD will be associated with both new and progressive periodontitis over time by increasing susceptibility to destructive periodontitis. We propose a longitudinal assessment of BMD and its role in establishment of periodontal disease in postmenopausal women with systematic studies using sensitive and accurate measures of skeletal and oral BMD, and periodontal disease. As part of the BMD assessment, we will further validate the methodology for oral BMD. In concert with these, assessment of a variety of potential co-risk factors for both low BMD and periodontitis will allow us to determine their contribution to this association. The systemic covariates include age, body mass index, smoking, alcohol, hormone use, socioeconomic and psychosocial factors, medications, medical and reproductive history, and diet. Local covariates include plaque, gingivitis, probing depth, previous dental care, and dental care habits. Study subjects will be recruited from an established cohort of postmenopausal women with baseline assessments of BMD and periodontitis as part of an ongoing cross-sectional study. We propose a 3-vear follow-up examination in 1000 postmenopausal women already enrolled in the NIH Women's Health Initiative study. To date, studies have not characterized the specific role of BMD either skeletal or mandibular on periodontal disease incidence and progression in a large cohort of postmenopausal women. Our preliminary cross-sectional studies have determined that skeletal BMD is associated with alveolar crestal height, tooth loss and clinical attachment loss. The proposed longitudinal study will have sufficient sample size and statistical power to assess the temporal relationship between BMD and periodontitis and the effects of a large set of co-risk factors and potential confounding factors affecting osteopenia, periodontal disease or both. This study provides a unique opportunity to define this relationship in a cost effective manner in a cohort of postmenopausal women under study as part of the Women's Health Initiative and has great practical significance. Low BMD is likely of considerable importance in the onset and progression of periodontitis. Hence once the relationship is established, modalities effective in the prevention and treatment of osteoporosis may prove useful for prevention and treatment of periodontitis and subsequent tooth loss.