Perceptions Of Benefits And Risks-Rakai

该协议已获得NIAID IRB(03-CC-NO39)的批准。本研究旨在通过从乌干达Rakai地区的研究参与者、社区成员和舆论领袖那里获得的经验数据，为发展中国家生物医学研究相关伦理问题的审议和解决提供信息。特别是，这项研究将着眼于发展中国家参与研究的人如何看待参与生物医学研究的社区的好处和风险。这项研究将评估人们对研究对他们社区的影响的看法。Rakai项目是乌干达西南部Rakai区正在进行的一项前瞻性队列研究。它在该地区的46个社区开展了以人群为基础的艾滋病毒/性传播疾病流行病学、行为和干预研究计划。将从Rakai区的社区中抽取具有代表性的男性和女性样本，包括：1)参与Rakai项目研究的人--包括因参与Rakai项目而获得经济补偿和没有获得经济补偿的人；2)从未被要求参与研究的人；3)拒绝参与研究的人；以及4)被所在社区视为领导者的人。接受采访的男性和女性将来自农村、农村和城市周边社区。这项研究的主要方法是对个人进行定量调查；次要方法是定性的、深入的个人访谈和焦点小组讨论。

This protocol has been approved by the NIAID IRB (03-CC-NO39) This study seeks to inform deliberation and resolution of ethical issues related to biomedical research in developing countries through empirical data obtained from research participants, community members, and opinion leaders in the Rakai District in Uganda. In particular, this study will look at how people involved in research in a developing country perceive the benefits and risks to communities involved in biomedical research. The study will assess people's perceptions of the effect of research on their communities. The Rakai Project is an ongoing prospective cohort study in the Rakai District of southwestern Uganda. It has an intensive population-based HIV/STD epidemiological, behavioral, and intervention research program in 46 communities in the district. A representative sample of men and women will be drawn from communities in the Rakai District to include: 1) people who have participated in Rakai Project research?including both those who have received financial compensation for their participation and those who have not, 2) people who have never been asked to participate in research, 3) people who have declined to participate in research, and 4) people who are perceived as leaders by their communities. Men and women interviewed will come from deep rural, rural, and peri-urban communities. The primary methodology of the study is a quantitative survey administered to individuals; a secondary methodology is qualitative in-depth individual interviews and focus group discussions.