Forkhead transcription factors in T lymphocytes

描述(申请人提供)：Fox/Forkhead家族包含越来越多的螺旋-环-螺旋转录因子，参与不同的生物系统。我们在这里描述了Foxj1的免疫作用，Foxj1是狐狸家族的成员，最初的特征是它在纤毛上皮细胞中的作用。在缺乏Th1的情况下，辅助性T(Th)细胞以Th1偏斜的过度增殖为特征，与多系统自体炎症相关。因此，Foxj1在维持T细胞静止和/或免疫耐受方面发挥着关键作用，但我们对其作用机制以及它在T细胞激活中的上下文重要性知之甚少。因此，我们建议在这一应用中进一步深入研究Foxj1在T细胞生物学中的作用-特别是更全面地研究其在Th增殖和激活中的作用，更充分地确定其与自身免疫的相关性，并阐明其作用的分子途径。

DESCRIPTION (provided by applicant): The Fox/forkhead family encompasses an ever-growing number of helix-loop-helix transcription factors that participate in diverse biological systems. We describe here an immune role for Foxj1, a Fox family member originally characterized for its role in ciliated epithelial cells. In its absence, helper T (Th) cells are characterized by Th1-skewed hyperproliferation, associated with multi-system auto-inflammation. As such, Foxj1 plays a critical role in the maintenance of T cell quiescence and/or immune tolerance, but we know relatively little about its mechanism of action, as well as its contextual importance in T cell activation. We therefore propose in this application to delve further into the role of Foxj1 in T cell biology - in particular to examine more completely its role in Th proliferation and activation, to determine more fully its relevance to autoimmunity, and to elucidate the molecular pathway in which it operates.