Inova 500 MHz Nuclear Magnetic Resonance System

描述：(由申请人提供)这份建议书概述了一项详细的计划，将一台新的500 MHz Inova核磁共振波谱仪集成到加州理工大学化学和化学工程部的仪器设施中。这种高场核磁共振仪器的主要应用将是确定合成、半合成和生物合成序列和方案所产生的复杂有机和无机分子结构的结构。该司七个主要用户组以及许多次要用户组(未列出)的研究活动将极大地受益于这台新的光谱仪，在许多情况下，现有计划内的新研究方向将因这种关键仪器的存在而成为可能。在过去的30年里，高场核磁共振波谱仪已经成为主要大学化学系的基础研究工具。核磁共振是一种非破坏性的表征方法，它以常规、高通量的方式提供关于无机和有机结构的几何和组成的独特、详细的信息。因此，这些仪器已经成为化学研究人员的主要分析工具，这些领域依赖于小分子和大分子结构的合成。更具体地说，数千个核磁共振波谱表征 实验每周在学术界和工业界的大多数传统化学系内进行。在这种情况下，加州理工学院化学和化学工程部目前用于500 MHz核磁共振分析的仪器基础设施非常有限。目前，该部门拥有一台布鲁克AMX 500 MHz光谱仪，该光谱仪是1986年购买的。这台光谱仪已经超过了预期的使用寿命。由于灵敏度差、分辨率差和软件过时而产生的限制使这一解释实际上已经过时，我们计划在不久的将来将该仪器从我们的设施中移除。此外，除了现有的部门仪器外，我们目前还有一台600兆赫的瓦里安Unity Plus仪器；该仪器几乎完全用于与复杂生物分子相关的结构测定。该系统所需的高灵敏度要求有效地排除了它作为常规或高吞吐量部门的使用 乐器。研究所已作出重大承诺，监督维持和实施技术专门知识，以便在较长的时间内使用这一仪器。这个 研究所和该司将为核磁共振设施经理的工资提供必要的资金，并提供必要的基础设施来容纳这一仪器。新的500兆赫仪器将与目前的分区核磁共振仪器安装在毗连的空间内。

DESCRIPTION: (provided by applicant) This proposal outlines a detailed plan to integrate a new 500 MHZ Inova NMR Spectrometer into the Instrumentation Facilities in the Division of Chemistry and Chemical Engineering at Caltech. The major application of this high field NMR instrument will be for the purpose of structure determination of complex organic and inorganic molecular architectures arising from synthetic, semisynthetic, and biosynthetic sequences and protocols. The research activities of seven major user groups, as well as many minor user groups (not listed) in the Division will greatly benefit from this new spectrometer and in many cases new research directions within existing programs will be enabled by the presence of such critical instrumentation. Over the last 30 years, high field NMR spectrometers have come to represent a fundamental research tool among major university chemistry departments. NMR is a non-destructive characterization method that provides unique, detailed information about the geometry and constitution of inorganic and organic structure in a routine, high-throughput fashion. As a consequence, these instruments have become the analytical workhorse for chemical researchers across a broad variety of fields that rely upon the synthesis of small and large molecular architecture. More specifically, thousands of NMR spectroscopy characterization experiments are performed on a weekly basis within most traditional chemistry departments in academia and industry. In this context, the current instrumentation infrastructure for 500 MHz NMR analysis in the Division of Chemistry and Chemical Engineering at Caltech is severly limited. At the present time, the department has one Bruker AMX 500 MHz spectrometer that was purchased in 1986. This spectrometer has exceeded its expected lifetime for usage. Limitations arising from poor sensitivity, poor resolution and outdated software has rendered this instruement effectively obsolete and we plan to remove this instrument from our facility in the near future. In addition, to the existing departmental instrumentation, we currently have a 600 MHz Varian Unity Plus instrument; that is used almost exclusively for structural determination associated with complex biological molecules. The requirements of high sensitivity that are required for this system effectively preclude its use as a routine or high throughput departmental instrument. The Institute has made a major committment to oversee the maintenance and implementation of technical expertise to operate this instrument over an extended time frame. The Institute and the Division will provide the necessary funds towards the salary of the NMR facility manager and resources to provide the necessary infrastructure to house this instrument. The new 500 MHz instrument will be housed in contiguous space with the current Division NMR instruments.