OMRF MRI SYSTEM

描述（由申请人提供）： 我们寻求资金帮助购买布鲁克BioSpec成像系统，以便为代表20多个NIH资助提案的约15名活跃的主要研究者和其他几位受资助的科学家进行小动物磁共振成像（MR 1）和光谱学（MRS）。该单位将代表该校区唯一的实验动物MRI系统，因此OMRF MRI设施将直接使OMRF/OUHSC校区的约50名科学家受益。所提议的MRI系统的使用将主要涉及其与涉及转基因动物模型的项目相关的成像能力。体内形态测量评估，包括在几种实验性转基因模型中评估癌症发展以及解剖学和骨骼变化的进展，将代表其预期用途的约一半。OMRF MRI设备的可用性将显著加快转基因操作和治疗模式的效果评估，并总体上有助于减少早期处死，从而减少所需实验动物的总数（即减少动物之间的变异），并促进实现各种项目的目标。涉及基础血管生物学的非常活跃的突出项目需要对比增强MRI和MR血管造影术来监测各种组织区域（例如心血管、hmg、脑）。功能性MRI在神经退行性疾病中的突出活动程序的应用代表了所提出设备的另一个主要用途。MRS还将用于评估含氢代谢物和高能磷酸盐，以研究致癌作用和各种神经退行性疾病。此外，将开发新的MRI技术，用于评估特定自由基的组织定位，重点是一氧化氮中间体和组织特异性对比增强。

DESCRIPTION (provided by applicant): We seek funds to help purchase a Bruker BioSpec Imaging System in order to do small animal magnetic resonance imaging (MR1) and spectroscopy (MRS) that is needed for about 15 active Principal Investigators representing over 20 NIH funded proposals and several other funded scientists. This unit would represent the only experimental animal MRI system on this campus and as such the OMRF MRI Facility would directly benefit about 50 scientists on the OMRF/OUHSC campus alone. Usage of the proposed MRI system would mostly involve its imaging capabilities associated with projects involving transgenic animal models. In vivo morphometetric assessment, including assessment of cancer development and the progression of anatomical and skeletal changes in several experimental transgenic models will represent about one-half of its intended use. The availability of the OMRF MRI facility would significantly speed up assessment of the effects of transgenic manipulations and treatment paradigms and overall help reduce early sacrificing hence reducing the total number of experimental animals needed (i.e. reduction of between animal variations) and enhance accomplishment of the goals of the various projects. Very active prominent programs involving fundamental vascular biology require contrast-enhanced MRI and MR angiography for monitoring various tissue regions (e.g. cardiovascular, hmg, brain). Functional MRI application for prominent active programs in neurodegenerative diseases represents another major use of the proposed equipment. MRS will also be used to assess hydrogen-containing metabolites and high-energy phosphates to study carcinogenesis and various neurodenerative diseases. Additionally, new MRI technology will be developed for assessing tissue localization of specific flee radicals with a focus on nitric oxide intermediates, and tissue-specific contrast enhancement.