Pulse Doppler Ultrasound Imaging System

描述(由申请人提供)： 该提案要求为最先进的脉冲多普勒超声心动图仪器、飞利浦HDI5000 SonoCT以及McKesson Horizon医学成像图像管理系统提供资金。该系统将为北德克萨斯大学健康科学中心(UNTHSC)的研究人员社区提供服务。该机构目前有一台超声波仪器可用于研究工作，但它已有9年历史，数据还原能力有限，没有能力在小动物身上进行超声波测量。所要求的超声波仪器是移动式的，可以随时访问HSC内的所有实验点，而图像管理系统将安装在固定的位置，以最大限度地提高数据分析能力。超声/图像管理系统是一种最先进的系统，它将使UNTHSC能够满足其研究人员目前和未来的需要，并使教学技术现代化。人们希望利用超声波仪器的广泛能力来收集体内心脏和血管系统对各种扰动的结构和功能适应的数据，包括肥胖、高血压、心力衰竭、衰老和运动。目前对超声/图像管理系统的研究需要包括确定：(I)在肥胖发展期间响应血压控制和/或运动训练的心脏的结构和功能适应，(Ii)肺动脉高压和右冠状动脉疾病的全球后果，(Iii)响应快速心室起搏引起的心肌病的心室重构，(Iv)在心脏骤停和心肺复苏后丙酮酸治疗对心肌收缩性能和脑灌注的影响(V)骨骼肌血管传导性和心输出量，以帮助评估静息和运动期间动脉压力感受器反射和肌肉血管的自主控制，和(Vi)老年人由于运动训练而产生的迷走心功能。来自综合生理学系的六个主要使用者都得到了NIH同行评审的研究拨款。此外，我们还确定了更多的部门用户，他们将受益于超声心动图的使用。最后，我们设想在骨科手法医学、临床医学、阿尔茨海默病研究和减肥医学领域招募其他健康科学中心的研究人员，以利用该仪器的能力。

DESCRIPTION (provided by applicant): This proposal requests funding for a state-of-the-art Pulse-Doppler ultrasound echocardiographic instrument, the Philips HDI5000 SonoCT, coupled with the McKesson Horizon Medical Imaging image management system. This system will serve a community of researchers at the University of North Texas Health Science Center (UNTHSC). There is currently one ultrasound instrument at the institution that is available for research work, but it is 9 years old, has limited data reduction capabilities, and does not have the capability to make ultrasound measurements in small animals. The requested ultrasound instrument is mobile which allows ready access to all experimental sites within the HSC, while the image management system will be housed in fixed locations in order to maximize data analysis capabilities. The ultrasound/image management system is a state-of-the-art system, which will enable UNTHSC to meet the current, and future needs of its researchers, as well as modernize teaching technology. It is hoped to take advantage of the broad capabilities of the ultrasound instrument in order to collect data on in vivo structural and functional adaptations of the heart and vasculature to a variety of perturbations, including obesity, hypertension, heart failure, aging, and exercise. Current research needs for the ultrasound/image management system include determining: (i) structural and functional adaptations of the heart in response to blood pressure control and/or exercise training during the development of obesity, (ii) global consequences of pulmonary hypertension and right coronary artery disease, (iii) ventricular remodeling in response to rapid ventficular pacing-induced cardiomyopathy, (iv) the impact of pyruvate therapy on myocardial contractile performance and cerebral perfusion following cardiac arrest and cardiopulmonary resuscitation (v) skeletal muscle vascular conductance and cardiac output to assist in assessing arterial baroreflex and autonomic control of the muscle vasculature at rest and during exercise, and (vi) vagal-cardiac function in the elderly as a result of exercise training.There are six major users from the Department of Integrative Physiology, all with NIH peer reviewed research grants. In addition, we have identified additional departmental users who would benefit from the use of ultrasound echocardiography. Finally, we envision recruiting other Health Science Center researchers in the fields of osteopathic manipulative medicine, clinical medicine, Alzheimer's disease research, and bariatric medicine to take advantage of the instrumentation's capabilities.