300 MHz NMR SPECTROMETER

描述（由申请人提供）：药物设计和发现领域的研究在很大程度上依赖于用于确定所研究分子在溶液中的化学结构、构象和动力学行为的光谱仪器。目前和可预见的未来，在开发新合成药物和从天然来源分离潜在药物时，用于评估这些结构特征的最重要的光谱工具之一是核磁共振（NMR）光谱。俄亥俄州州立大学药学院药物化学和生药学系的教师、学生和研究人员有着以创造性的方式共享使用NMR光谱仪的悠久传统，以促进国家认可的药物设计和发现研究。该NCRR共享仪器拨款申请要求提供资金，用于购买Bruker Avance 300 FT/NMR光谱仪系统（配备7.05特斯拉超导磁体）、具有X核观测和去耦功能的射频发射机系统、数字采集控制系统、计算机工作站和软件、数字可变温度控制单元以及5 mm宽带观测探头。所要求的300 MHz NMR将取代已有15年历史的250 MHz Bruker AC 250光谱仪，该光谱仪在我们药学院的共享仪器设施中用作处理大量较短持续时间NMR实验的“主力”仪器。多年来，250 MHz频谱仪为我们提供了异常可靠的服务，但AC 250已经变得更加过时，不可靠，并且由于零件可用性的减少几乎不可能维修。这一对300 MHz NMR光谱仪系统的要求代表了最具成本效益的，有能力的光谱仪，以适应我们不断增长的约45人的本地用户群，包括药物化学教师，研究生和博士后研究人员。

DESCRIPTION (provided by applicant): Research in the areas of drug design and discovery relies heavily on spectroscopic instruments used to determine the chemical structure, conformation, and dynamic behavior in solution of the molecules being studied. At present and for the foreseeable future, one of the most important spectroscopic tools used to assess these structural features in the development of new synthetic drugs and the isolation of potential drugs from natural sources is nuclear magnetic resonance (NMR) spectroscopy. The faculty members, students, and research personnel of the Division of Medicinal Chemistry and Pharmacognosy in the College of Pharmacy of The Ohio State University have a long tradition of shared use of NMR spectrometers in creative ways to facilitate nationally recognized research in drug design and discovery. This NCRR Shared Instrumentation grant application requests funds for the purchase of the Bruker Avance 300 FT/NMR spectrometer system with 7.05 Tesla superconducting magnet, rf transmitter system with X-nucleus observe and decouple capabilities, digital acquisition control system, computer workstation and software, digital variable temperature control unit, and a 5 mm broadband observe probe. The requested 300 MHz NMR will replace a 15-year old 250 MHz Bruker AC250 spectrometer that has served as the "workhorse" instrument for handling large numbers of shorter duration NMR experiments in our shared instrument facility in the College of Pharmacy. The 250 MHz spectrometer provided us with unusually reliable service over the years, but the AC250 has become more obsolete, unreliable and nearly impossible to repair due to diminishing parts' availability. This request for a 300 MHz NMR spectrometer system represents the most cost effective, capable spectrometer to accommodate our growing local user group of about 45 individuals, consisting of medicinal chemistry faculty members, graduate students, and post-doctoral researchers.