Acuson Sequoia Ultrasonograph

描述（由申请人提供）： 本修正提案的目的是获得一种具有高空间和时间分辨率的最先进的心脏超声仪，用于小动物表型分析。该仪器用于获得心脏和大血管的M模式、2-D和多普勒超声心动图，用于高通量心血管分析，以及基因工程小鼠和其他心血管疾病动物模型的详细解剖生理研究。该仪器还具有对非心脏结构进行连续成像的潜力，在该应用中，研究人员建议将其用于评估多囊肾疾病和颗粒细胞瘤。 该工具的主要用户包括NIH同行评审的研究者发起的研究奖的获奖者和获奖者。这些生物医学研究人员来自多个学科，包括医学，儿科学，遗传学，生理学和生物物理学，药理学，解剖学和病理学。来自CWRU各个部门的NIH赞助的研究人员的核心在啮齿动物和小鸡中进行研究;这些研究人员已经表达了兴趣，并通过过去一年半的讨论和随后的合作努力，已经认识到超声心动图评估对其研究计划的至关重要性。

DESCRIPTION (provided by applicant): The objective of this amended proposal is to acquire a state-of-the-art cardiac ultrasonograph with high spatial and temporal resolution to be used for small animal phenotype analysis. The instrument is used to obtain M-mode, 2-D and Doppler echocardiograms of the heart and great vessels for high-throughput cardiovasculm analysis, and detailed anatomic-physiologic studies in genetically engineered mice and other animal models of cardiovascular disease. The instrument also has the potential for serial imaging of non-cardiac structures, and in this application, investigators propose its use in evaluating polycystic renal disease and granulosa cell tumors. The major users of this instrument include recipients and of NIH peer-reviewed investigator initiated research awards. These biomedical investigators hail from multiple disciplines, including medicine, pediatrics, genetics, physiology and biophysics, pharmacology, anatomy, and pathology. This core of NIH-sponsored investigators from a variety of Departments at CWRU perform studies in rodents and chicks; these investigators have expressed an interest in, and through discussions and subsequent collaborative efforts spanning the past year and one-half, have recognized the critical importance of an echocardiographic evaluation for their research programs.