CANCER CENTER SUPPORT GRANT (CCSG)

佛蒙特州伯灵顿的佛蒙特州癌症中心(VCC)是一个基于矩阵的癌症中心，位于佛蒙特州大学校园内。自1974年成立以来，佛蒙特州癌症中心一直致力于为佛蒙特州人民及其纽约北部邻居提供研究、教育和服务的使命。虽然是NCI指定的最小的综合癌症中心之一，但它在密歇根大学医学院的核心作用，以及它所服务的农村和相对稳定的人口的不同寻常的性质，为整合与癌症相关的基础、临床和以人群为导向的研究创造了理想的环境。提出了四个研究计划。其中两个以基础研究为基础(1-基因组稳定性和表达研究计划；2-细胞信号和生长控制研究计划)，但通过1)分子/机制或2)细胞/生物水平的研究，与癌症作为一种疾病有明显的联系。临床研究计划的重点是治疗和转化性研究，重点关注乳腺癌、妇科和泌尿生殖系统癌症。最后，该中心的癌症预防和控制研究项目在一级和二级癌症预防方面进行了一系列以人群为基础的研究，重点是行为研究。对乳腺癌、烟草控制和癌症遗传风险因素的关注为这一久负盛名的计划提供了基础。九项共享资源或支持服务，其中两项是中心新推出的。它们包括：细胞成像设备、DNA分析设备、飞行细胞测量设备、玻璃器皿清洗设备、分子建模设备、分子方法核心、生物统计学核心、临床研究管理核心和特定于协议的支持。还要求为试验研究和招募对中心研究任务至关重要的调查人员提供发展资金。

The Vermont Cancer Center (VCC), in Burlington, Vermont, is a matrix- based Cancer Center located on the campus of the University of Vermont. Since its founding in 1974, the Vermont Cancer Center has ben committed to its mission in research, education and service to the people of the Vermont and their neighbors in northern New York. Although one of the smallest NCI-designated Comprehensive Cancer Centers, its central role in the UVM College of Medicine, and the unusual nature of the rural and relatively stable population it serves, have created an ideal environment for integration of basic, clinical and population-directed research related to cancer. Four Research Programs are presented. Two are strongly grounded in basic research (1-Genome Stability and Expression Research Program; 2- Cell Signaling and Growth Control Research Program) but have clear links to cancer as a disease through studies at the 1) molecular/mechanistic, or 2) the cellular/biological level. The Clinical Research Program has an emphasis on therapeutic and translational research with focused interests on breast, gynecologic and genitourinary cancers. Finally, the Center's Cancer Prevention and Control Research Program conducts a range of population-based studies in primary and secondary cancer prevention, with a strong emphasis on behavioral research. Focused interests in breast cancer, tobacco control, and genetic risk factors for cancer have provided the foundation for this well- established program. Nine-Shared Resources or support services are presented, including two that are new to the Center. They include: Cell Imaging Facility, DNA Analysis Facility, Fly Cytometry Facility, Glassware Washing Facility, Molecular Modeling Facility, Molecular Methods Core, Biostatistics Core, Clinical Research Management Core, and Protocol-specific Support. Developmental funds for pilot studies and recruitment of investigators critical to the Center's research mission are also requested.