CORE-4-BIOSTATISTICS AND INFORMATION SYSTEMS

脑癌杜克大学SPORE的生物统计学和信息学核心支持SPORE中所有项目和核心的统计，生物信息学和信息系统需求。该核心是由癌症中心生物统计学和癌症中心信息系统（CCIS）合作开发的。Stephen L.博士乔治博士，癌症中心生物统计学主任和CALGB集团统计师和癌症中心信息系统主任金伯利约翰逊是核心的共同主任。 博士乔治将指导这一领域的生物统计和生物信息学举措，而约翰逊女士将指导信息系统举措，并协助乔治博士管理核心。CCIS在癌症中心内由乔治博士进行行政监督。 该核心的其他工作人员包括统计人员和程序员，他们根据自己的专业领域和过去与个别项目的联系，专门负责每个项目和核心。除核心主任外，还要求为3名统计人员（全时当量共计0.70）、1名生物信息学家（全时当量共计0.10）、2名信息系统人员（全时当量共计0.55）和1名全职数据管理员提供部分支助。 该核心将为临床、临床前和实验室研究以及遗传研究的统计分析提供帮助。此外，该核心将支持研究数据库结构和数据管理活动的发展。核心将利用现有的计算基础设施资源作为支持SPORE研究的有效手段，并将在基础设施开发方面取得成功。该核心可用的资源包括CCIS支持的25台服务器，提供超过20 GB的内存和2 TB的磁盘空间，具有多处理能力以及各种软件应用程序和编译器。

The Biostatistics and Informatics Core for the Duke SPORE in Brain Cancer supports the statistical, bioinformatics and information systems needs of all projects and cores in the SPORE. The Core was developed as a collaboration between Cancer Center Biostatistics and Cancer Center Information Systems (CCIS). Dr. Stephen L. George, Ph.D., Director of Cancer Center Biostatistics and Group Statistician for the CALGB and Kimberly Johnson, Director of Cancer Center Information Systems are Co-Directors of the Core. Dr. George will direct biostatistics and bioinformatics initiatives in this area, while Ms. Johnson will direct information systems initiatives and assist Dr. George in administering the Core. CCIS falls under the administrative oversight of Dr. George within the Cancer Center. Additional staff for this Core includes statisticians and programmers dedicated to each project and core based on their area of expertise and past associations with individual projects. In addition to the core directors, partial support is requested for three statistical personnel (.70 FTE total), one bioinformatician (.10 FTE), two information systems personnel (.55 FTE total) and one full-time data manager. This Core will provide assistance in the statistical analysis of clinical, pre-clinical and laboratory studies, as well as genetic investigations. In addition, the Core will support the development of research database structures and data management activities. The Core will use existing computing infrastructure resources as an efficient means to support SPORE research and will build on past successes in infrastructure development. Resources available to this Core include 25 servers supported by CCIS, offering over 20GB of memory and 2 TB of disk space with multi-processing capabilities and a variety of software applications and compilers.