Development of Noninvasive Perfusion Measurement System

描述(由申请人提供)： 建议开发一种用于血液灌注量定量测量的非侵入性热系统。主要目标是设计和制造一种易于使用、自动化和准确的临床设备，适用于各种应用。将开发和测试两种不同的初步设计，以展示它们不同的操作和安全特性。由于血液灌注量代表了通过活组织的毛细血管和细胞内空间的局部、多方向的血液流动，因此很难用绝对值来量化。因此，第二个目标是开发一种标准的体外系统，用于血流灌注测量系统的绝对校准。在该校准装置中，两种不同的建议热系统将与激光多普勒系统一起进行比较，以确定相对于绝对标准的性能。这些测量系统还将通过在大鼠身上进行体内测试进行比较。在这个为期两年的项目结束时，将设计、建造和测试一个校准系统和两个测量系统。根据评估的绩效，将在今后的研究中利用兽医学校、维克森林医学院和附属于弗吉尼亚理工大学的Carilion生物医学研究所的资源进行适当的申请。

DESCRIPTION (provided by applicant): It is proposed to develop a non-invasive thermal system for quantitative measurement of blood perfusion. The main goal is to design and build a clinical device that will be easy to use, automated and accurate for a wide variety of applications. Two different preliminary designs will be developed and tested to demonstrate their different features of operation and safety. Because blood perfusion represents the local, multi-directional blood flow through capillaries and intracellular spaces of living tissue, it is difficult to quantify with absolute values. Consequently, a second goal is to develop a standard in-vitro system for absolute calibration of perfusion measurement systems. Two different proposed thermal systems will be compared along with a laser Doppler system in this calibration device to determine performance against an absolute standard. The measurement systems will also be compared by testing in vivo in rats. At the end of this two year project a calibration system and two measurement systems will have been designed, built, and tested. Based on their assessed performance the appropriate applications will be pursued in future studies using the resources of the Veterinary School, the Wake Forest Medical School and the Carilion Biomedical Institute affiliated with Virginia Tech.