Understanding Neuroplasticity Induced by TrYptamines (UNITY)

5-羟色胺能迷幻药作为一种治疗一系列疾病的新型精神病学干预药物，具有广泛的治疗潜力。它们还能促进健康人群的心理健康。尽管有这些演示，但我们对迷幻药后的治疗变化机制知之甚少。一个可能的候选因素是神经可塑性，尽管很少有直接测试。这个项目使用功能磁共振成像(FMRI)研究了单次注射二甲基色胺(DMT)后人脑网络结构的变化。网络测量将被用来预测酗酒者的临床相关益处以及典型人群的幸福感改善。

Serotonergic psychedelics have broad therapeutic potential as a novel psychiatricintervention across a range of disorders. They also promote mental wellbeing in 'healthy'people. Despite these demonstrations, we have little insight into the mechanisms oftherapeutic change following psychedelics. A likely candidate is neural plasticity though therehave been few direct tests. This project examines changes in the network organization of thehuman brain after a single administration of dimethyltryptamine (DMT) using functionalmagnetic resonance imaging (fMRI). Network measures will be used to predict clinicallyrelevant benefits in heavy drinkers and improvements in well-being in typical populations.