Acute Alcohol and Nicotine Interactions in Men and Women

描述(申请人提供)：拟议研究的目的是调查尼古丁和酒精消费之间的关系。几项研究已经证实吸烟和饮酒之间存在强烈的正相关性，但这种关联背后的确切机制尚不清楚。此外，很少有研究对样本进行分层，以检查酒精和烟草之间的性别差异。第一个目标是研究急性饮酒是否以剂量和肢体依赖的方式增加对香烟的渴望，并检查男性是否比女性对酒精引起的香烟渴望表现出更多的敏感性。虽然已经有研究研究了饮酒对伴随而来的吸烟或嗜好的影响，但很少有研究探讨其反向途径(即尼古丁对饮酒的影响)。因此，第二个目标是确定尼古丁暴露是否会增加饮酒欲望和饮酒量，并检查此类反应中的性别差异。了解男性和女性酒精和尼古丁相互作用潜在的独特生物行为机制，可能有助于制定专门针对性别的早期预防和治疗计划。

DESCRIPTION (provided by applicant): The purpose of the proposed studies is to investigate the relationships between nicotine and alcohol consumption. Several studies have established a strong positive association between cigarette smoking and alcohol use, but the exact mechanisms underlying this association are unknown. Also, few studies have stratified their samples to examine gender differences in the link between alcohol and tobacco. The first goal is to examine whether acute alcohol consumption increases cigarette craving in a dose and BAC-limb dependent manner, and to examine if men show more sensitivity to alcohol-induced cigarette craving compared to women. Although studies have examined the effects of alcohol consumption on concomitant cigarette smoking or craving, there is a paucity of research examining the reverse pathway (i.e., effects of nicotine on alcohol consumption). Therefore, the second goal is to determine whether nicotine exposure increases alcohol craving and consumption, and to examine gender differences in such responses. Understanding the potential unique biobehavioral mechanisms underlying alcohol and nicotine interactions for men and women may help to tailor early prevention and treatment programs specifically for the sexes.