COURSE OF COGNITIVE FUNCTIONING IN LATE LIFE DEPRESSION

这是K01MH01684-01A1的再申请，请求支持为申请人提供必要的技能，以开展将老年神经心理学与神经影像学和纵向数据分析联系起来的研究。职业发展活动将侧重于结构和功能MRI方法和数据解释，以及多元和纵向数据分析技能。这些技能将应用于晚年抑郁症（LLD）的认知功能过程的研究，在晚年情绪障碍心理健康干预研究中心的主持下。该中心为受试者提供基础广泛的临床评估，包括基线、急性抑郁发作治疗后的神经心理学评估，以及每年的随访。通过该中心收集的临床神经心理学和结构MRI数据，以及在本MRSDA主持下收集的补充认知和功能MRI数据，将对250名LLD和90名老年对照受试者的认知过程进行为期四年的研究。与治疗相关的认知变化将被描述。认知功能障碍的危险因素将被确定。使用有效和可靠的功能性MRI探针，将在一部分受试者中检查背外侧前额叶皮层的功能完整性。在四年的随访期内，本研究将根据认知过程确定和表征LLD亚组，并检查未来痴呆的危险因素。该奖项将为申请人提供资源，以获得必要的培训，以启动一系列程序性研究，并发展成为一名独立的科学家。

This is a resubmission of K01MH01684-01A1 requesting support to provide the applicant with the skills necessary to conduct research that bridges geriatric neuropsychology with neuroimaging and longitudinal data analysis. Career development activities will focus on structural and functional MRI methods and data interpretation, and multivariate and longitudinal data analytic skills. These skills will be applied to research on the course of cognitive functioning in late-life depression (LLD), under the auspices of the Mental Health Interventions Research Center in Late-Life Mood Disorders. The Center provides subjects with broad-based clinical assessments, including neuropsychological evaluation, at baseline, after treatment of acute depressive episodes, and at yearly follow-up. The cognitive course of 250 LLD and 90 elderly control subjects will be studied over four years, using clinical neuropsychological and structural MRI data collected through the Center, as well as supplementary cognitive and functional MRI data collected under the auspices of this MRSDA. Treatment-related cognitive changes will be characterized. Risk factors for cognitive dysfunction will be determined. The functional integrity of the dorsolateral prefrontal cortex will be examined in a subset of subjects, using a valid and reliable functional MRI probe. Over a four-year follow-up period, this research will identify and characterize LLD sub-groups based on cognitive course, and examine risk factors for future dementia. This award will provide the applicant with the resources to obtain the training necessary to initiate a line of programmatic research and to develop into an independent scientist.