CORE--ISLET CELL AND FUNCTIONAL ANALYSIS

描述(由申请人提供) 建议的胰岛细胞和功能分析核心(IFAC)的目的是通过准备和维护胰岛实验模型并提供分析工具来分析其功能，从而刺激和支持涉及胰岛生理和病理生理作用的研究。IFAC将是自1991年以来一直由细胞和组织核心赞助的胰岛细胞卫星(ICS)的扩展。人们对小岛研究的兴趣日益浓厚，卫星也日趋成熟，因此有必要在行政上将岛屿研究中心重新归类为一个单独的核心，并扩大其资源。核心的主要重点是为附属调查员的项目准备胰岛，包括质量保证在内的功能评估，以及开发新的功能评估技术。胰岛细胞卫星目前支持大约15名研究人员的研究；然而，随着服务和资源的扩大，这一数字可能会增加到20多项。总的来说，IFAC将提供的服务范围是：1)生产胰岛和与胰岛相关的材料；2)采购人类和非人类灵长类组织和器官的中央资源；3)维持培养中的胰岛组织；4)利用生化和成像技术对胰岛进行急性和慢性功能评估；5)培训工作人员，并就胰岛和胰岛细胞工作提供咨询。这些资源的提供将在促进西雅图地区众多研究所和研究中心以小岛为基础的研究方面发挥不可或缺的作用。

Description (Provided by applicant) The purpose of the proposed Islet Cell and Functional Analysis Core (IFAC) is to stimulate and support research involving the physiologic and pathophysiologic role of pancreatic islets, both by preparing and maintaining islet experimental models and providing the analytical tools to analyze their function. The IFAC will be an expansion of the Islet Cell Satellite (ICS) that since 1991 has been under the auspices of the Cell and Tissue Core. The increased interest in islet research and the maturation of the satellite warrants that the ICS be reclassified administratively as a separate Core and its resources expanded. The major focus of the Core is preparation of islets for Affiliate Investigator's projects, functional evaluation including quality assurance, and the development of novel functional assessment technologies. The Islet Cell Satellite currently supports about 15 investigator's research; however, expansion of services and resources will likely increase this number to more than 20. Overall, the scope of services that IFAC will provide are 1) production of islets and islet-related materials; 2) a central resource for the procurement of human and non-human primate tissues and organs; 3) maintenance of islet tissue in culture; 4) acute and chronic functional assessment of islets using biochemical and imaging technology; 5) and training of staff and consultation in islet and islet cell work. The provision of these resources will play an integral part in facilitating islet-based research in the numerous institutes research centers in the Seattle area.