Liver Center

描述(由申请人提供) 加州大学旧金山分校肝脏中心是一家 由基础和临床科学家组成的跨学科联盟致力于 了解肝脏的生物学和病理生物学及其治疗 肝脏疾病。自1975年成立以来，它经历了不断的 进化以应对当前的科学挑战，及其执行委员会 监测研究进展，提出开拓新领域的举措。这个 当前中心研究的主线表现为五条相互联系的 主题：(1)免疫学；(2)新陈代谢、损伤和修复；(3)遗传学和 发展；(4)肝癌；(5)病毒性肝炎。三 主题-免疫学、遗传学和发育以及肝癌-已经出现 在本供资期间通过招募新成员和 与有组织的研究单位结盟。过去两年的一项重大举措 几年来一直参与加州大学旧金山分校的癌症中心，并导致准备了一项 NCI孢子在肝癌中的应用。该中心支持四核 设施：(1)细胞和组织生物学；(2)临床和翻译 研究；(3)显微镜和先进成像；(4)分子分析。这四个科学核心不仅提供直接的研究 支持，但却是新协作的场所和新合作的切入点 会员。最后，该中心通过来访的科学家促进科学交流 计划，研讨会系列，及其年度科学务虚会。在2000-01年度 一学年，这些项目带来了五位基础生物学领域的顶尖研究人员 或翻译科学，其工作与研究特别相关 中心的主题。该中心继续扩大对会员的支持 通过战略合作伙伴关系进行科学研究，最近一次是与退伍军人 加州大学旧金山分校癌症中心和生物医学研究生项目 科学。除了这些关系外，该中心还与 加州大学旧金山分校的免疫学和发育生物学课程。它的资金基础继续增长，来自该机构的支持也得到了持续 而且很强壮。基础生物学与BASIC应用的机遇 对临床肝病的科学从未像现在这样伟大，而该中心是 准备催化在这些领域的发现。

DESCRIPTION (provided by applicant) The Liver Center of the University of California, San Francisco is an inter-disciplinary consortium of basic and clinical scientists dedicated to understanding the biology and pathobiology of the liver and the treatment of liver diseases. From its inception in 1975, it has undergone continual evolution to meet current scientific challenges, with its Executive Committee monitoring research progress and creating initiatives to open up new areas. The main lines of Center research at present are represented by five inter-related themes: (1) Immunology; (2) Metabolism, Injury and Repair; (3) Genetics and Development; (4) Liver Cancer; and (5) Viral hepatitis. Three themes-Immunology, Genetics and Development, and Liver Cancer-have emerged during the current funding period through recruitment of new members and alliances with organized research units. A major initiative over the past two years has involved the UCSF Cancer Center and resulted in preparation of an application for an NCI SPORE in liver cancer. The Center supports four core facilities: (1) Cell and Tissue Biology; (2) Clinical and Translational Research; (3) Microscopy and Advanced Imaging; (4) Molecular Analysis. The four scientific Cores not only provide direct research support but are a venue for new collaborations and an entry point for new members. Finally, the Center fosters scientific exchange through a Visiting Scientist Program, a Seminar Series, and its Annual Scientific Retreat. In the 2000-01 academic year, these programs brought five leading researchers in basic biology or translational science whose work has particular relevance to the research themes of the Center. The Center continues to expand its support of member science through strategic partnerships, most recently with the Veterans Administration, the UCSF Cancer Center, and the graduate program in Biomedical Sciences. In addition to these affiliations, the Center enjoys close links with the UCSF programs in Immunology and Developmental Biology, respectively. Its funding base continues to grow, and support from the institution is sustained and strong. The opportunities in basic biology and in the application of basic science to clinical liver disease have never been greater, and the Center is poised to catalyze discovery in these areas.