CANCER CENTER SUPPORT GRANT (CCSG)

佛蒙特州癌症中心（VCC）位于佛蒙特州伯灵顿市，是一个基于矩阵的癌症中心，位于佛蒙特大学校园内。自1974年成立以来，佛蒙特州癌症中心一直致力于研究，教育和服务于佛蒙特州及其北部邻居的使命。虽然是nci指定的最小的综合癌症中心之一，但它在UVM医学院的核心作用，以及它所服务的农村和相对稳定人口的不寻常性质，为癌症相关的基础、临床和人口导向研究的整合创造了一个理想的环境。提出了四个研究项目。其中两个是基于基础研究（1-基因组稳定性和表达研究计划；2-细胞信号传导和生长控制研究计划），但通过1)分子/机制或2)细胞/生物学水平的研究，与癌症作为一种疾病有明确的联系。临床研究项目侧重于乳腺癌、妇科和泌尿生殖系统癌症的治疗和转化研究。最后，该中心的癌症预防和控制研究项目开展了一系列以人群为基础的原发性和继发性癌症预防研究，重点是行为研究。对乳腺癌、烟草控制和癌症的遗传危险因素的关注为这个建立良好的项目提供了基础。介绍了九种共享资源或支持服务，其中两种是中心的新服务。这些设施包括：细胞成像设施、DNA分析设施、流式细胞仪设施、玻璃器皿洗涤设施、分子建模设施、分子方法核心、生物统计学核心、临床研究管理核心和特定协议支持。还要求为试点研究和征聘对中心研究任务至关重要的调查人员提供发展资金。

The Vermont Cancer Center (VCC), in Burlington, Vermont, is a matrix- based Cancer Center located on the campus of the University of Vermont. Since its founding in 1974, the Vermont Cancer Center has ben committed to its mission in research, education and service to the people of the Vermont and their neighbors in northern New York. Although one of the smallest NCI-designated Comprehensive Cancer Centers, its central role in the UVM College of Medicine, and the unusual nature of the rural and relatively stable population it serves, have created an ideal environment for integration of basic, clinical and population-directed research related to cancer. Four Research Programs are presented. Two are strongly grounded in basic research (1-Genome Stability and Expression Research Program; 2- Cell Signaling and Growth Control Research Program) but have clear links to cancer as a disease through studies at the 1) molecular/mechanistic, or 2) the cellular/biological level. The Clinical Research Program has an emphasis on therapeutic and translational research with focused interests on breast, gynecologic and genitourinary cancers. Finally, the Center's Cancer Prevention and Control Research Program conducts a range of population-based studies in primary and secondary cancer prevention, with a strong emphasis on behavioral research. Focused interests in breast cancer, tobacco control, and genetic risk factors for cancer have provided the foundation for this well- established program. Nine-Shared Resources or support services are presented, including two that are new to the Center. They include: Cell Imaging Facility, DNA Analysis Facility, Fly Cytometry Facility, Glassware Washing Facility, Molecular Modeling Facility, Molecular Methods Core, Biostatistics Core, Clinical Research Management Core, and Protocol-specific Support. Developmental funds for pilot studies and recruitment of investigators critical to the Center's research mission are also requested.