Treatment of lung cancer

描述（由申请人提供）：肺癌是美国癌症死亡的主要原因。这位候选人一直致力于肺癌的临床和转化研究，希望改善这种毁灭性疾病的治疗效果。一个有成就的领域是用放化疗治疗低风险肺癌患者。研究者的另一个专业领域是利用紫杉醇的放射增敏和抗血管生成特性来改善非小细胞肺癌（NSCLC）的放化疗。该候选人是第一个报道紫杉醇体内抗血管生成特性的研究人员。临床试验已经证明了每周两次紫杉醇和卡铂联合放疗治疗III期NSCLC的可行性和有效性。在基础和转化研究中，候选人使用组合化学和细胞生长试验技术鉴定了肺癌细胞表面受体特异性肽配体。一项由R21资助的试点研究正在测试使用这些肽从恶性胸腔积液中捕获癌细胞的可行性。候选人正在申请K-24奖，以支持他实现以下目标的努力：在加州癌症协会进行一项nci赞助的II期试验，以测试替拉帕胺与先前建立的每周两次紫杉醇和卡铂联合放射治疗III期NSCLC的耐受性和有效性。一项相关研究将探讨测量血浆缺氧诱导蛋白、纤溶酶原激活物抑制剂I型（pal - 1）和血管内皮生长因子（VEGF）与放化疗前后肿瘤反应的相关性的可行性。2. 进一步发展肽头技术作为一种高产、高通量的临床方法，从胸腔液中分离和富集肺癌细胞。这项技术可能有助于肺癌的诊断。3. 鉴定肺癌特异性新肽配体。长期目标是开发这些肽配体作为肺癌的分子靶向治疗。4. 招募和培训血液学和肿瘤学专家从事癌症治疗的临床研究。

DESCRIPTION (provided by applicant): Lung cancer is the leading cause of cancer death in the United States. The candidate has devoted to clinical and translational research of lung cancer with the hope of improving outcomes for this devastating disease. An area of accomplishment is in the treatment with chemoradiotherapy for poor-risk patients with lung cancer. Another area of expertise of the investigator is in capitalizing the radiosensitizing and antiangiogenic properties of taxol for improving chemoradiotherapy of non-small-cell lung cancer (NSCLC). The candidate was the first researcher to report the in vivo antiangiogenic property of taxol. Clinical trials have demonstrated the feasibility and efficacy of twice-weekly taxol and carboplatin with concurrent radiation for stage III NSCLC. In basic and translational research, the candidate has identified peptide ligands specific for surface receptors of lung cancer cells using the technology of combinatorial chemistry and cell-growth-on-bead assay. A pilot study is being supported by a R21 grant to test the feasibility of using these peptides to capture cancer cells from malignant pleural effusion. The candidate is applying for a K-24 award to support his endeavor of achieving the following aims: 1. To conduct a NCI-sponsored phase II trial in the California Cancer Consortium to test the tolerance and efficacy of tirapazamine in combination with the previously established regimen of twice-weekly taxol and carboplatin with concurrent radiation for stage III NSCLC. A correlative study will explore the feasibility of measuring plasma hypoxia-induced proteins, plasminogen activator inhibitor type I (PAl-l) and vascular endothelial growth factor (VEGF), in association with tumor response before and after chemoradiotherapy. 2. To further develop the peptide-bead technology as a high-yield and high-throughput clinical procedure for isolating and enriching lung cancer cells from pleural fluid. This technology may facilitate the diagnosis of lung cancer. 3. To identify novel peptide ligands specific for lung cancer. The long-term goal is to develop these peptide ligands as molecularly targeted therapy for lung cancer. 4. To recruit and train hematology and oncology specialists in clinical research of cancer therapy.