INNER EAR FLUID INTERACTIONS

描述：（改编自研究者摘要）脑脊液 干扰是一个主要因素，在一些病理影响的内部 耳，如梅尼埃病。我们研究的目的是提供一个 内淋巴体积诊断和治疗的科学依据 干扰.采用了基于敏感技术的直接方法， 测量体内内淋巴体积和流量。通过这些措施，我们将 建立了一些影响内淋巴体积的方法，包括 次声和低频音调和压力脉冲传递到 耳蜗液或耳道。听骨运动引起的一些这些 刺激可与由中间肌肉收缩引起的刺激相比较 其已经显示产生内淋巴运动。的机制 体积干扰和有助于体积恢复的干扰将被 研究了在体积操作期间，用于量化的间接方法 内淋巴体积的变化将与直接测量 内淋巴横截面积。这些研究将有助于改善 内淋巴积水的诊断测试第二个项目将审查 内淋巴囊在操作过程中发生的生理变化 耳蜗内淋巴体积。电解质的大小和时间过程 将在扰动期间测量SAC的变化。时间进程和 囊的诱导解剖学变化的空间分布将是 记录和量化使用三维磁共振显微镜，光和 电镜内淋巴囊所起的功能作用将 被纳入溶质分散的定量数学模型， 内耳这些研究将确定可能的机制， 调节内淋巴体积，并将导致更复杂的方法， 治疗内淋巴体积紊乱。他们还将指导未来的研究， 体积调节的特定方面的组织和过程。的 整个项目将建立基本的生理过程 有助于内淋巴容量调节，并将与 耳蜗液性疾病的临床诊断和治疗。

DESCRIPTION: (Adapted from the Investigator's Abstract) Cochlear fluid disturbances are a major facto in a number of pathologies affecting the inner ear, such as Meniere's disease. The goal of our studies is to provide a scientific basis for the diagnosis and treatment of endolymph volume disturbances. A direct approach is used, based on sensitive techniques, which measure endolymph volume and flow in vivo. Using these measures, we will establish a number of methods, which influence endolymph volume, including infrasonic, and low frequency tones and pressure pulses delivered to the cochlear fluids or ear canal. Ossicular movements induced by some of these stimuli are comparable to those induced by middle middle muscle contractions which have been shown to generate endolymph movements. Mechanisms underlying volume disturbance and those contributing to volume recovery will be investigated. During volume manipulations, indirect methods for quatifying endolymph volume changes will be correlated with direct measurements of endolymphatic cross-sectional area. These studies will lead to improved diagnostic tests for endolymphatic hydrops. A second project will examine physiologic changes occurring in the endolymphatic sac during manipulations of endolymph volume in the cochlea. The magnitude and time course of electrolyte changes in the sac will be measured during disturbances. The time course and spatial distribution of induced anatomical changes of the sac will be documented and quantified using 3-D magnetic resonance microscopy, light and electron microscopy. The functional role played by the endolymphatic sac will be incorporated into quantitative mathematical models of solute dispersion in the inner ear. These studies will identify possible mechanisms by which the sac regulates endolymph volume and will lead to more sophisticated methods for treating endolymph volume disturbances. They will also direct future studies to the tissues and processes underlying specific aspects of volume regulation. The project as a whole will establish the fundamental physiological processes contributing to endolymph volume regulation and will have relevance to the clinical diagnosis and treatment of cochlear fluid disorders.