Micropower Potentiostat for Implantable Glucose Sensors

描述(由申请人提供)： 需要开发植入式传感器来持续监测糖尿病患者的血糖。我们之前开发了一种基于固定化葡萄糖氧化酶和氧电极的植入式葡萄糖传感器，并在犬体内使用该传感器进行了100多天的静脉植入，而无需重新校准。我们现在已经开发了一种新的基于组织的传感器设计，以潜在地应用于广泛的糖尿病人群，但进一步的开发需要目前尚不存在的专门电子电路。拟议的项目是第二阶段的工作，以完成新型微功率恒电位仪的开发，主要用于植入式葡萄糖传感器，但也可能与其他植入型传感器和设备一起应用。在第一阶段，我们启动了传感器长期运行所需的超低功耗恒电位仪电路的开发，并成功地展示了一种独特的、新的集成恒电位仪电路设计的可行性。与此同时，我们一直在开发传感器本身，以及必要的密封平台，以容纳器械并将传感器运送到植入部位。有了这些其他所需的元素，现在就应该启动电子开发项目的第二阶段，并完成长期植入式葡萄糖传感器系统的这一关键元素。

DESCRIPTION (provided by applicant): There is a need for development of implantable sensors for continuous monitoring of glucose in diabetes. We previously developed an implantable glucose sensor based on immobilized glucose oxidase coupled to an oxygen electrode and employed the sensor as an intravenous implant for over 100 days in dogs without recalibration. We have now developed a new tissue-based sensor design for potential application to a broad portion of the diabetic population, but further development requires specialized electronic circuitry not currently available. The proposed project is a Phase II effort to complete the development of novel micropower potentiostat instrumentation, principally for the implantable glucose sensor, but that may also find application with other implantable sensors and devices. In Phase I, we initiated development of the ultra-low power potentiostat circuitry needed for long-term operation of the sensor, and successfully demonstrated the feasibility of a unique, new integrated potentiostat circuit design. In parallel efforts, we have been developing the sensor itself, as well as the necessary hermetically sealed platform to contain the instrumentation and deliver the sensor to the implant site. With these other required elements in hand, it is now appropriate to initiate Phase II of the electronics development project and complete this key element of the long-term implantable glucose sensor system.