Recoverable Homogeneous Chiral Phosphine Ligands

描述（由申请人提供）：本项目（第一阶段和第二阶段合并）致力于开发均相催化剂库，可通过液/液方法回收，用于不对称氢化。Polium Technologies，Inc正在为该项目寻求SBIR资金，因为我们看到行业对此类产品的需求很大，但如果没有外部资金，公司无法负担其开发费用。该项目的重要性是1600亿美元的单一对映体药品市场对新手性技术的巨大需求的直接结果。在该项目过程中开发的技术将大大简化昂贵手性催化剂的大规模分离和回收。这将提高预期手性催化方法的成本效益，使其对制造更广泛的单一对映体化合物具有吸引力。2002年，这类技术的市场为70亿美元，预计到2009年将达到150亿美元。在第一阶段，Polium Technologies，Inc将进行可行性研究。具体而言，我们将（a）从几种最常用的手性膦配体开始，制备几种可通过液/液萃取回收的均相催化剂;（B）证明这些催化剂在模型氢化反应中的活性。截至2003年7月29日，还没有关于通过液/液方法可回收的用于不对称合成的催化体系或其在催化中的用途的出版物或专利。

DESCRIPTION (provided by applicant): This project (Phase I and Phase II combined) is devoted to the development of a library of homogeneous catalysts, recoverable through liquid/liquid methods, used for asymmetric hydrogenation. Polium Technologies, Inc is seeking SBIR funds for this project because we see a significant demand for such products from industry, but the company cannot afford their development without external funding. The significance of this project is a direct consequence of a huge demand for new chiral technologies fueled by the $160 billion market of single-enantiomer pharmaceutical products. Technology developed in the course of this project would significantly simplify the large-scale separation and recycling of expensive chiral catalysts. This would increase cost-effectiveness of prospective chiral catalytic processes, making them attractive to manufacture a wider range of single-enantiomer compounds. In 2002, the market for such technologies was $7 billion, and it is projected to reach $15 billion by 2009. in Phase I Polium Technologies, Inc will perform a feasibility study. Specifically we will (a) prepare several homogeneous catalysts recoverable by liquid/liquid extraction, starting from several of the most frequently used chiral phosphine ligands; (b) demonstrate activity of these catalysts in model hydrogenation reactions. As of July 29, 2003, there are no publications or patents on catalytic systems for asymmetric synthesis recoverable by liquid/liquid processes or their use in catalysis.