Examining the role of extracellular myeloperoxidase in the pathogenesis, identification and treatment of high-risk unstable and ruptured atherosclerotic plaque

血管炎症已成为中风和心脏病发作的关键驱动因素和治疗靶点。现有的诊断技术和治疗方法并不针对炎症，因此残余的炎症风险仍然存在。有必要确定可能从治疗中受益的活动性炎症患者。髓过氧化物酶是一种炎症酶，存在于有破裂和随后中风或心脏病发作风险的斑块中，是一种潜在的诊断工具和治疗靶点。

Vascular inflammation has emerged as a key driver and therapeutic target for stroke and heart attack. Existing diagnostic techniques and treatments do not target inflammation so that residual inflammatory risk remains. There is a need to identify patients with active inflammation who may benefit from treatment. Myeloperoxidase is an inflammatory enzyme abundant in plaque at risk of rupture and subsequent stroke or heart attack and presents as a potential diagnostic tool and therapeutic target.