Miniature digital telemetric bioelectric recording

描述（由申请人提供）：我们将改进一种廉价的微型电池供电的数字遥测系统（DT）的无线电组件，用于神经科学的新应用。DT利用商业上可用的数字音频集成电路和协议来记录、存储和传输生物电信号，而无需有线。第一阶段是基于一个原型，旨在记录自由移动大鼠大脑中单个神经元的活动。DT版本4（DT 4）原型有16个输入，10克，使用18克电池运行> 4小时。DT 4以24位分辨率对信号进行数字化，可分辨小至10 uV的信号。每个输入都经过低通滤波（6 kHz）和数字化（12 kHz）。数字信号被组合成单个数据流，然后通过光纤或2.4 GHz无线电信道将串行化数据传输到基于DSP的远程记录系统。DT 4的测量结果超过了当前的标准，但由于多径反射以及Wi-Fi和蓝牙设备，当射频干扰（RFI）很高时，当前的无线电传输是不可靠的。具体目标1是在DT中使用RRM技术以实现可靠的无线电传输。可拆卸1是一个2通道无线模块。可扩展2是基于8个2通道模块的16通道无线系统。表3是通过记录自由移动大鼠的神经元集合来表征和测试可交付成果2。对于非交互式应用，如果记录设备本身（通常是PC）不是便携式的，则无线记录并不有利。具体目标2是建立一个原型DT与无线USB的动物研究。将为可扩展4开发DT的系留USB版本。一旦无线USB控制器可用，用无线等效物取代“有线”USB芯片组应该相对简单;如果后者可用，可扩展5将是基于无线USB标准的原型DT。在第二阶段，为了将该设备商业化用于神经科学研究，我们将减小设备的尺寸和成本，并朝着实现临床使用的DT迈出第一步。

DESCRIPTION (provided by applicant): We will improve the radio component of an inexpensive, miniature battery-operated digital telemetric system (DT) for new applications in neuroscience. DT exploits commercially available digital audio integrated circuits and protocols to record, digitize, and transmit bioelectric signals without wires. Phase 1 is based on a prototype designed to record the activity of ensembles of single neurons from the brains of freely-moving rats. The DT version 4 (DT4) prototype has 16 inputs, is 10g and operates >4h from an 18g battery. DT4 digitizes signals at 24-bit resolution, allowing signals as small as 10 uVto be resolved. Each input is lowpass filtered (6 kHz) and digitized (12 kHz). The digital signals are combined into a single data stream and the serialized data are then transmitted to a remote DSP-based recording system via either an optical fiber or a 2.4 GHz radio channel. Measurements by DT4 surpass current standards, but the current radio transmission is unreliable when radio frequency interference (RFI) is high due to multi-path reflections and Wi-Fi and Bluetooth devices. Specific aim 1 is to use RRM techniques in the DT for reliable radio transmission. Deliverable 1 is a 2-ch wireless module. Deliverable 2 is a 16-ch wireless system based on eight 2-ch modules. Deliverable 3 is to characterize and test deliverable 2 by recording ensembles of neurons in freely-moving rats. For non-interactive applications, wireless recording is not advantageous if the recording device itself (usually a PC) is not also portable. Specific aim 2 is to build a prototype DT with wireless USB for animal research. A tethered USB version of the DT will be developed for Deliverable 4. Once a wireless USB controller is available, replacing the "wired" USB chipset by its wireless equivalent should be relatively straightforward; if the latter is available, Deliverable 5 will be a prototype DT based on the wireless USB standard. In Phase II, to commercialize the device for neuroscience research we will reduce the device's size and cost and make first steps towards realizing a DT for clinical use.