Development of APMS as a Chromatographic Substrate

描述（由申请人提供）：酸制备的介孔二氧化硅（“APMS”）在高效液相色谱（“HPLC”）中显示出与市售二氧化硅相比的重大进步，高效液相色谱是一种通常用于分离分子的技术。与商用高效液相色谱柱相比，含有APMS的高效液相色谱柱显着提高了分子保留时间和峰对峰分辨率。这些好处是由于APMS的物理特性，它由规则的5微米球体组成，表面积为1100平方米/克。本研究主要有三个目标：(1)开展APMS的规模化生产研究；(2)拓展已有的手性分离研究；(3)研究APMS在排色色谱中的潜在应用。本研究的最终目标是生产一套高效液相色谱柱材料。HPLC色谱柱市场价值5亿美元，并以每年8%的速度增长。由于HPLC是一种标准的研究工具，APMS的成功商业化将通过加速对基本生命过程的理解而使社会和研究人员受益。特别是，APMS可以促进液相色谱-质谱（LC-MS），粒径排除色谱（SEC）和手性分离。

DESCRIPTION (provided by applicant): Acid-prepared mesoporous silica ("APMS") shows significant advances over commercially available silica in high performance liquid chromatography ("HPLC"), a technique commonly used to isolate molecules. HPLC columns containing APMS show dramatically enhanced molecular retention times and improved peak-to-peak resolutions compared to commercial HPLC columns. These benefits are due to the physical properties of APMS, which consists of regular 5 um spheres with a surface area of 1100 m2/g. The proposed research has three main goals: (1) to initiate studies on larger-scale production of APMS; (2) to expand previous studies on chiral separations; and (3) to study the potential uses of APMS in size-exclusion chromatography. The ultimate goal of this research will be to produce a suite of HPLC column materials. The HPLC columns market is $500M and growing at 8% annually. Because HPLC is a standard research tool, successful commercialization of APMS will benefit society and researchers by accelerating the major advances in understanding fundamental life processes. In particular, APMS could facilitate liquid chromatography-mass spectrometry (LC-MS), size exclusion chromatography (SEC), and chiral separations.