Symposium on Retinal/ Choroidal Angiogenesis

描述(申请人提供)：在发达国家，视网膜和脉络膜血管生成占所有失明的大部分。由于其对经济和生活质量的深刻影响，眼部血管生成是一个被广泛研究的过程，该领域正在以惊人的速度发展。因此，管理来自对眼和视网膜血管生成感兴趣的越来越多的研究人员的信息变得越来越困难。现在是时候总结一下，把重点放在集体研究的重要和潜在有益的方面，并总结我们迄今的进展。即将举行的视网膜和脉络膜血管生成研讨会的主要目标是促进基础和临床科学家之间当前信息和思想的交流，以促进我们对血管生成眼部疾病的基本机制和治疗干预措施的理解取得进展。已作出特别努力，鼓励新的研究人员参加，招募具有临床和基础科学背景的现有研究人员，并为两个小组提供充分的互动机会。我们在这个领域已经达到了一个点，基础和临床科学家在了解这些视网膜疾病背后的基本机制方面存在着强烈的共同兴趣。这次会议将负责促进合作研究项目，这些项目将提供重要的新信息。研讨会将汇集众多研究人员，从细胞和发育生物学家到来自全美主要研究/临床中心的临床医生和科学家。会议将于2004年10月15日至16日在田纳西州纳什维尔举行。该计划将有8个平台会议，专门用于海报演示的时间，以及2个主题演讲。该计划已经完成，包括视网膜和脉络膜血管生成的分子和细胞机制的基本信息，血管生成视网膜疾病的体外和动物模型的详细描述，新机制理论在人类疾病发病机制中的应用，以及治疗这些疾病的新治疗策略。主旨演讲将由来自肿瘤血管生成领域的两名全国知名的研究人员发表。克鲁沃学术出版社将以书籍的形式出版研讨会的会议记录，每位受邀的演讲者将贡献一章。J·唐纳德·M·加斯医学博士已经同意写一篇导言。在这项申请中，我们要求提供资金，以支持20名年轻调查人员和2名主旨发言人的旅费和注册费。

DESCRIPTION (provided by applicant): Retinal and choroidal angiogenesis accounts for the majority of all blindness in developed countries. Because of its profound economic and quality-of-life impact, ocular angiogenesis is an intensely studied process and the field is advancing at an alarming pace. Thus, it is becoming increasingly difficult to manage the information coming from the growing group of investigators interested in ocular and retinal angiogenesis. It is time to take stock, to focus on the important and potentially beneficial aspects of the collective research, and to summarize our progress to date. The primary goal of the forthcoming Symposium on Retinal and Choroidal Angiogenesis is to promote the exchange of current information and ideas among basic and clinical scientists in order to foster advances in our understanding of basic mechanisms and development of therapeutic interventions for angiogenic eye conditions. Special effort has been made to encourage new investigators to attend, to recruit established investigators with both clinical and basic science backgrounds, and to provide ample opportunity for the two groups to interact. We have reached a point in this field where there is strong common interest among basic and clinical scientists in understanding the fundamental mechanisms underlying these retinal conditions. This meeting will be responsible for fostering collaborative research projects that will provide vital new information. The symposium will feature a rich mixture of investigators, ranging from cell and developmental biologists to clinician-scientists from major research/clinical centers throughout the U.S. The meeting will be held in Nashville, TN on October 15 - 16, 2004. The program will have 8 platform sessions, dedicated time for poster presentations, and 2 keynote lectures. The program is finalized and includes basic information on molecular and cellular mechanisms of retinal and choroidal angiogenesis, detailed descriptions of in vitro and animal models of angiogenic retinal conditions, applications of new mechanistic theories to human disease pathogenesis, and novel therapeutic strategies for treatment of these conditions. The keynote lectures will be delivered by two nationally known investigators from the field of tumor angiogenesis. Kluwer Academic Publishers will publish the proceedings of the symposium in the form of a book, with each invited speaker contributing a chapter. J. Donald M. Gass, M.D. has agreed to write an introduction. In this application we request funds to support travel and registration costs of 20 young investigators and 2 keynote speakers.