Conference on Diabetes Mellitus

描述(由申请人提供)： 目前肥胖和糖尿病的流行是对全世界现代健康的主要威胁之一。肥胖通常被认为是大多数人患糖尿病的先决条件，但这两种疾病之间的确切关系仍然不清楚。世界上许多领先研究人员的实验室工作已经开始将肥胖症和脂肪细胞生物学的各个方面整合到胰岛素作用和分泌的研究中，糖尿病和肥胖症专家之间的沟通需求比以往任何时候都更加重要。小鼠遗传操作的最新进展使人们能够理性地研究细胞和生物背景下代谢调节的基本遗传和分子机制。这些研究工作成功地利用了小鼠遗传学、实验模型系统、基因组学和蛋白质组学技术以及传统的生理学和分子和细胞生物学工具，对这种疾病产生了令人兴奋的新见解。特别是新的发现涉及胰岛素信号和膜转运之间的接口；β细胞发育和凋亡；脂肪细胞向大脑、β细胞、肝脏和肌肉发送信号；以及细胞因子在胰岛素抵抗中的作用。会议(与肥胖大会联合举行)的目标将是汇聚该领域几个交叉领域的科学家，例如糖尿病新技术的应用；干细胞和发育生物学；受调控的膜运输；新陈代谢和基因表达的整合；以及治疗学。这次会议的一个主题是，基于组织培养和破碎细胞系统的研究与小鼠和其他非哺乳动物模式生物的研究不断相互作用和互惠互利。要考虑的广泛主题包括1)分子过程如何管理和协调组织间的代谢途径，3)特殊代谢调节与诸如增殖、分化、凋亡和生长等一般过程之间的关系，以及3)神经元控制食欲、生长和新陈代谢的分子决定因素。

DESCRIPTION (provided by applicant): One of the major threats to modern health throughout the world is the current epidemic of obesity and diabetes mellitus. Obesity is generally regarded as a prerequisite for the development of diabetes in most individuals, and yet the precise relationship between these two diseases remains obscure. Work in the laboratories of many of the leading investigators in the world has begun to integrate aspects of obesity and fat cell biology into studies of insulin action and secretion, and the need for communication between scientists expert in diabetes and obesity is more crucial than ever. Recent advances in the genetic manipulation of mice have allowed rational investigation into the basic genetic and molecular mechanisms of metabolic regulation in both a cellular and organismal context. These research efforts have successfully utilized the technologies of mouse genetics, experimental model systems, genomics, and proteomics as well as the traditional tools of physiology and molecular and cell biology to yield exciting new insights into this disease. Particularly novel findings relate to the interface between insulin signaling and membrane trafficking; beta cell development and apoptosis; adipocyte signaling to brain, beta cells, liver and muscle; and the role of cytokines in insulin resistance. The goal of the meeting (held jointly with the Obesity conference) will be to bring together scientists working in several intersecting areas of the field, e.g., the application of new technologies to diabetes; stem cell and developmental biology; regulated membrane trafficking; integration of metabolism and gene expression; and therapeutics. One theme of the conference is the constant interplay and mutual benefit of investigations based in tissue culture and broken cell systems with those in mouse and other non-mammalian model organisms. Among the broad themes to be considered will be 1) how molecular process govern and coordinate metabolic pathways among tissues, 3) the relationship between specialized metabolic regulation and such generalized processes as proliferation, differentiation, apoptosis growth, and 3) molecular determinants in the neuronal control of appetite, growth and metabolism