FASEB Summer Research Conference on Small G-Proteins

描述（由申请人提供）：我们想申请FASEB会议的部分资金“小GTP酶的调节和功能”将于7月10日至15日在斯诺马斯，科罗拉多举行。 小的GTdR超家族包括一组超过100个密切相关的分子开关，这些分子开关在进化过程中高度保守，并且似乎调节许多细胞生物学过程。 该家族包括Ras蛋白，其在人类肿瘤发生的背景下被深入研究; Rho蛋白，其作为细胞骨架的关键调节剂发挥作用;以及Rab蛋白，其是囊泡运输和分泌的主要调节剂。 会议将包括来自这些领域的许多最杰出的研究人员的演讲。 会议的组织方式强调了这些不同的家庭成员之间的生化调节的相关方面，以及新兴的主题，即各种小GTP酶介导的信号通路之间存在大量的串扰。因此，一个重要的目标是促进这一领域的调查人员之间的互动和潜在的合作。 小GTP酶已直接涉及几个重要的人类健康问题，包括癌症，糖尿病和高血压，并将有演讲，解决这些蛋白质在正常生物学以及疾病过程中的作用。 本次会议将有约200人参加，其中44人将受邀演讲。 此外，将从一组提交的摘要中选出8名发言者作简短介绍。 会议将涵盖各种小GTP酶及其调节剂和目标的生物化学，结构和功能方面。

DESCRIPTION (provided by applicant): We would like to request partial funding for a FASEB conference on "Regulation and Function of Small GTPases" to be held on July 10-15 in Snowmass, Colorado. The small GTPase superfamily comprises a group of more than 100 closely related molecular switches that have been highly conserved through evolution, and which appear to regulate numerous cell biological processes. This family includes, among others, the Ras proteins, which have been studied intensively in the context of human oncogenesis, the Rho proteins, that function as key regulators of the cytoskeleton, and the Rab proteins, that are major regulators of vesicle trafficking and secretion. The conference will include presentations from many of the most prominent researchers in each of these fields. The sessions have been organized in such a way as to emphasize the related aspects of biochemical regulation among these distinct family members as well as the emerging theme that there is substantial cross-talk between the various small GTPase-mediated signaling pathways. Thus, an important goal is to promote interactions and potential collaborations among investigators in this field. The small GTPases have been directly implicated in several important human health problems, including cancer, diabetes, and hypertension, and there will be presentations that address the role of these proteins in both normal biology as well as in disease processes. There will be approximately 200 participants in this conference, among which, 44 will be invited speakers. In addition, 8 speakers will be selected for short presentations from a group of submitted abstracts. The conference will cover the biochemical, structural, and functional aspects of the various small GTPases and their regulators and targets.