FASEB Summer Conference on Neuroimmunology

描述（由申请人提供）：本申请是为了支持将于2004年8月7-12日在亚利桑那州图森举行的第八届FASEB神经免疫学夏季研究会议。在过去的十年里，来自不同学科的科学家开始对免疫系统和神经系统之间的串扰感兴趣。越来越多的证据表明，在正常和病理情况下，免疫因子和免疫细胞在中枢神经系统中发挥作用，中枢神经系统调节外周免疫反应。快速发展使得有必要重新评估中枢神经系统-免疫相互作用的一些基本方面，包括解剖，生理和功能方面。以前，对免疫参与中枢神经系统的兴趣仅限于脑自身免疫性疾病。然而，中枢神经系统创伤和神经退行性疾病今天被认为具有炎症成分。例子包括阿尔茨海默病、艾滋病相关痴呆、帕金森病、脑外伤和脊髓损伤。另一方面，一些中枢神经系统产品下调外周免疫，对脓毒性休克和自身免疫性疾病等病理状况有有益作用。这改变了我们对自身免疫和神经退行性疾病治疗方法的看法。在2004年FASEB会议上，我们计划就免疫介质在中枢神经系统炎症和神经保护中的作用、中枢神经系统产物的免疫调节作用、与免疫细胞中枢神经系统转运和免疫特权部位功能建立相关的分子机制等基本问题展开讨论。关于中枢神经系统抗原呈递细胞的起源和功能、中枢神经系统的病毒靶向、中枢神经系统自身免疫的有益和有害影响等问题将被提出。最后，本次会议的一个主要推力将是探讨炎症在中枢神经系统创伤和神经退行性疾病中的作用和机制。这次会议为基础和临床神经免疫学的科学讨论提供了一个急需的平台。

DESCRIPTION (provided by applicant): This application is a request for support for the 8th FASEB Neuroimmunology Summer Research Conference to be held in Tucson, AZ, August 7-12, 2004. In the last decade, scientists from different disciplines became interested in the cross talk between the immune and nervous system. Accumulating evidence suggests that immune factors and cells play a role in the CNS in normal and pathological conditions, and that the CNS regulates peripheral immune responses. Rapid advances make it necessary to reassess a number of basic aspects of CNS-immune interactions, including anatomical, physiological, and functional aspects. Previously, interest in the immune involvement in the CNS was limited to brain autoimmune diseases. However, CNS trauma and neurodegenerative diseases are recognized today as having inflammatory components. Examples include Alzheimer's disease, HIV associated dementia, Parkinson's disease, brain trauma, and spinal cord injury. On the other hand, several CNS products downregulate peripheral immunity, having a beneficial effect on pathological conditions such as septic shock and autoimmune diseases. This alters our view of therapeutic approaches for the treatment of both autoimmune and neurodegenerative diseases. At the 2004 FASEB meeting, we plan to expand on basic issues regarding the role of immune mediators in CNS inflammation and neuroprotection, on the immunomodulatory role of CNS products, and on the molecular mechanisms related to immune cell CNS trafficking and the functional establishment of the immune privileged sites. Questions will be raised regarding the origin and function of CNS antigen presenting cells, viral targeting of the CNS, beneficial and detrimental effects of CNS autoimmunity. Finally, a major thrust of this conference will be to explore the role and mechanisms of inflammation in CNS trauma and neurodegenerative diseases. This meeting provides a much needed platform for scientific discussions in both basic and clinical neuroimmunology.