Ubiquitination and Cellular Regulation

描述(由申请人提供)： 题为“泛素与细胞调节”的FASEB夏季会议将于2004年6月26日至7月1日在佛蒙特学院举行。我们要求为这次会议(2004年、2006年和2008年)提供部分多年资助。FASE B自1989年以来一直赞助泛素化的领先会议，当时这一领域已经发展到临界质量。会议每两年举行一次，但目前的情况除外，上次会议是在2001年。会议的任务已及时改变，以应对不断变化的实地情况。曾经，该领域每个主要实验室的PI都有望发表25分钟的演讲。90年代末，随着这一领域的爆炸性发展，S变得有必要仔细地关注最新和最重要的发展。上一次会议非常成功，59%的与会者认为这是他们参加过的最好的会议。我们努力把新来者引入实地，缩短了会谈时间，以便能够提出更广泛的进展。以前的形式，即从摘要中挑选出来的简短演讲被降级到最后一天，这种形式被放弃了，这些人有机会与更成熟的研究人员一起发言。我们将在2004年大体上遵守这些新的公约，预计它们将再次受到发言者和非发言者的欢迎。 泛素和泛素样蛋白领域继续以惊人的速度扩大，不断有新的实验室加入，强调了在这样的会议上将人们聚集在一起的重要性。泛素化在人类疾病中日益增长的重要性是众所周知的。显然，超过5%的基因组致力于植物的泛素化。对哺乳动物也做出了类似的估计。正如诺贝尔奖得主迈克尔·布朗在谈到最近授予泛素研究人员的拉斯克奖时所说的那样，泛素“是生物学的核心……我估计目前生物学期刊上每10篇论文中就有一篇涉及泛素……”会议将突出在受邀发言者的选择和从摘要中挑选的多个演讲方面取得的突破性进展。将特别注意让新的和任职人数不足的调查员小组发言。这个位置并不适合在漫长的下午滑雪，但这次会议有着紧张的海报会议的杰出传统。根据过去的经验，会议将大幅超额认购。为了促进与会者之间的强烈互动，会议限制在大约175名与会者之间。

DESCRIPTION (provided by applicant): A FASEB summer conference entitled "Ubiquitin and Cellular Regulation" will be held June 26-July 1, 2004, at Vermont Academy. We request partial multi-year funding for this conference (2004, 2006, and 2008). FASEB has sponsored the leading conference on ubiquitination since 1989, when this field grew to a critical mass. The meeting is held biennially, except in the present case, where the last meeting was in 2001. The mission of the meeting has shifted in time, in response to the changing landscape of the field. At one time, the PI of every major lab in the field could expect to deliver a 25-min talk. In the late 90's, as the field exploded, it became necessary to focus carefully on the newest and most significant developments. The last meeting was highly successful, having been rated by 59% of participants as the best meeting they had ever attended. We strained to bring in newcomers to the field and shortened the talks so that a wider range of advances could be presented. The prior format, in which short talks selected from abstracts were relegated to the last day was abandoned, and these individuals had the chance to speak alongside more established researchers. We will generally keep to these new conventions in 2004, anticipating that they will again be well-recieved by speakers and nonspeakers. The field of ubiquitin and ubiquitin-like proteins continues to expand at a striking pace, with new labs constantly joining, emphasizing the importance of bringing people together at such a meeting. The growing importance of ubiquitination in human disease is well-recognized. Over 5% of the genome is apparently devoted to ubiquitination in plants. Similar estimates have been made for mammals. As stated by Nobel prize winner Michael Brown in regard to the recent Lasker award to ubiquitin reserachers, it "is at the very core of biology...I estimate that 1 in 10 papers in current biology journals deal with ubiquitin..." The meeting will highlight breaking advances both in the choice of invited speakers and in multiple talks selected from abstracts. Special attention will be made to give the floor to new and underrepresented groups of investigators. The location does not make for long afternoons skiing, but rather this conference has an outstanding tradition of intense poster sessions. Based on past experience, the conference will be oversubscribed by a large margin. To foster strong interactions among participants, the conference is limited to approximately 175 participants.