Nuclear Receptors: Steroid Sisters

描述（由申请人提供）：类固醇激素受体是配体依赖的细胞内转录因子，参与从生殖到脂质和矿物质稳态的多种生理过程。此外，类固醇受体功能失调与许多疾病的病理有关。这次类固醇受体会议的重点将放在这类转录调节因子的作用机制上。本次会议将包括讲座和广泛讨论雌激素、黄体酮、糖皮质激素、矿物皮质激素、雄激素和维生素D受体介导的信号转导的最新进展。通过强调一类受体，而不是一种疾病状态或一种特定的激素，我们相信促进不同背景的科学家之间的互动的目标可以最好地实现。这次会议与孤儿核受体姊妹会议的联系反映了组织者希望在一个地点聚集代表核受体社区全部范围的科学家。我们希望通过全体会议、专题讨论会和简短谈话的形式，以及广泛的海报会议，在一个促进与会科学家之间富有成效的互动的论坛上，重点介绍过去几年在这一领域取得的重大进展。

DESCRIPTION (provided by applicant): The steroid hormone receptors are ligand-dependent intracellular transcription factors involved in a diverse array of physiological processes ranging from reproduction to lipid and mineral homeostasis. In addition, dysregulation of steroid receptor function has been implicated in the pathology of many diseases. The focus of this Keystone Meeting on Steroid Receptors will be on the mechanism of action of this class of transcriptional regulators. This meeting will incorporate lectures and extensive discussions on the latest advances in estrogen, progestin, glucocorticoid, mineralocorticoid, androgen and vitamin D receptor-mediated signal transduction. By emphasizing a class of receptors, rather than a disease state or a specific hormone, we believe that the goal of facilitating interactions between scientists with different backgrounds can best be achieved. The linking of this conference to its sister conference on orphan nuclear receptors reflects the organizers desire to assemble in one venue scientists who represent the full breadth of the nuclear receptor community. Using plenary, symposium and short talk formats together with extensive poster sessions we hope to spotlight the major advances that have occurred in this field over the past few years in a forum that will facilitate productive interactions between participating scientists.