Society for Inherited Metabolic Disorders Annual Meeting

描述(由申请人提供)： 遗传性代谢疾病协会(SIMD)请求支持其 年会将于2002年3月3日至6日在阿西洛马举行。支持也是 要求举行2003年年度会议，与 在澳大利亚布里斯班举行的新陈代谢先天错误国际会议 以及将在美国举行的2004年和2005年年会。全 所要求的资金将专门用于允许受训人员和初级科学家 来参加会议。先天性中间代谢错误(IEM)是 智力低下，脑瘫，神经肌肉疾病， 心脏疾病、肝肾功能障碍、关节炎、糖尿病、生长 失败和失明。因为它们的广泛的临床和分子光谱 疾病正在被阐明，受影响的个人数量很多 比最初想象的要大，影响到1-3/1000的新生儿。识别 这些障碍中有相当大的扩展是由于引入 在许多州扩大了新生儿筛查。对其产生原因和原因的研究 这些先天代谢错误的机制改善了诊断，并 导致了对其中许多疾病的有效治疗，但还剩下很多 去做。这项研究也使我们对 中间代谢的基础科学，信号转导，中枢 神经系统功能、细胞内靶向和基本遗传机制。 这种知识的增长对于保持创新方面的进步至关重要 治疗这些严重疾病的方法。对于美国来说，要在这方面保持领先地位 重要的研究和临床应用领域，必须吸引 进入该领域的年轻调查人员。实现这一目标的一个有效机制是 为他们提供参加SIMD会议的机会， 他们可以受到启发去研究这一领域，并与其他人建立科学联系 老牌调查员。 SIMD会议每年举行一次，与会者，特别是年轻人 由于NIH的支持，调查人员的数量一直在增加。参与 妇女和少数群体也从这种支持中受益。是否可以使用 学员和初级科学家的旅行资金继续减少，因为 学术健康中心预算缩水。我们已经设计了科学计划 将尖端临床和基础研究纳入IEM。它包括以下内容 其他关于治疗先天性错误的新临床试验的会议 新陈代谢、结构生物学研究进展及其对新陈代谢的影响 IEMS，以及IEMS管理中的营养问题。在往年的基础上，我们 预计将提交30-50份摘要，供#年年会提交 美国。提交的文件可能会是国际比赛水平的2-3倍 开会。旅行基金的申请将以竞争性的方式审查五项 在年会前几个月。审查委员会，其中包括 这项资助的申请者将审阅摘要，并选择获得资助的摘要 旅游大奖。评选将基于科学价值和与 先天的新陈代谢错误。优先旅行奖将在#年颁发给研究员 培训、女性初级科学家、女性和少数民族科学家。NIH对这一申请的支持将极大地促进美国调查人员继续走在这一激动人心的前沿 和不断扩大的领域。

DESCRIPTION (provided by applicant): The Society for Inherited Metabolic Disorders (SIMD) requests support for its annual meeting to be held in Asilomar on March 3-6, 2002. Support is also requested for the 2003 annual meeting, to be held in conjunction with the International Congress on Inborn Errors of Metabolism in Brisbane, Australia, and for the 2004 and 2005 annual meetings to be held in the United States. All of the funds requested will be devoted to permit trainees and junior scientists to attend the meeting. Inborn errors of intermediary metabolism (IEM) are an important cause of mental retardation, cerebral palsy, neuromuscular disease, cardiac disorders, hepatic and renal dysfunction, arthritis, diabetes, growth failure, and blindness. As the wide clinical and molecular spectrum of these disorders is being elucidated, the number of affected individuals is much larger than originally thought, affecting 1-3/1000 of babies born. Recognition of these disorders has expanded considerably due to the introduction of expanded newborn screening in many states. Research into the causes and mechanisms of these inborn errors of metabolism has improved diagnosis and has led to effective treatment for many of these conditions, but there is much left to do. This research has also led to substantive increases in our knowledge of the basic science of intermediary metabolism, signal transduction, central nervous system function, intracellular targeting, and basic genetic mechanisms. This increase in knowledge is essential to maintain progress in innovative therapies for these severe disorders. For the US to remain pre-eminent in this important area of research and clinical application, it is essential to attract young investigators into the field. One effective mechanism to achieve this is to provide them with the opportunity to participate in the SIMD meeting, where they can be inspired to research the field and develop scientific ties to other established investigators. The SIMD meeting is held annually and participation, especially by young investigators, has been increasing due to support from the NIH. Participation by women and minorities also benefits from this support. The availability of travel funds for trainees and junior scientists continues to diminish as academic health center budgets shrink. We have designed the scientific program to include cutting edge clinical and basic research in IEM. It includes among others sessions on new clinical trials for treatment of inborn errors of metabolism, advances in structural biology and their impact of the study of IEMs, and nutritional issues in management of IEMs. Based on previous years, we expect submission of 30-50 abstracts for presentation at the annual meetings in the US. Submissions will likely be 2-3 times this level for the international meeting. Applications for travel funds will be competitively reviewed five months prior to the annual meeting. The review committee, which includes the applicants for this grant, will review the abstracts and select those granted travel awards. The selection will be based on scientific merit and relevance to inborn errors of metabolism. Priority travel awards will be given fellows in training, women junior scientists, and women and minority scientists. NIH support of this application will greatly facilitate US investigators remaining in the forefront of this exciting and expanding field.