Weight Loss During Treatment of Hepatitis C in HIV

描述(申请人提供)：丙型肝炎病毒(丙型肝炎病毒)现在是人类免疫缺陷病毒(HIV)合并感染患者最常见的死亡原因。在美国，三分之一的HIV感染者同时感染了丙型肝炎病毒。HIV/丙型肝炎病毒混合感染与肝纤维化、肝硬变和肝功能衰竭的快速进展有关。因此，丙型肝炎病毒的治疗对于HIV/丙型肝炎病毒感染患者的长期生存至关重要。然而，据报道，70%的艾滋病毒/丙型肝炎患者在接受丙型肝炎病毒治疗期间体重严重下降，这可能导致提前停止或修改丙型肝炎病毒治疗。由于这种副作用可以阻止晚期肝病高危患者接受最佳治疗，因此需要确定接受艾滋病毒/丙型肝炎双重治疗的艾滋病毒/丙型肝炎患者的发病率和体重减轻程度。研究还可以阐明体重减轻的风险因素，可以加强对其背后的生物学机制的理解。这项回溯性队列研究旨在检查接受双重治疗的艾滋病毒/丙型肝炎患者与1)接受丙型肝炎病毒治疗的单一丙型肝炎病毒感染者和2)只接受艾滋病毒治疗的艾滋病毒单一感染者相比体重减轻的发生率。减肥的风险因素也将被检查。这项流行病学研究的结果可能最终有助于对HIV/丙型肝炎患者进行最佳的丙型肝炎治疗，并为评估伴随体重减轻而出现的身体成分和代谢异常的变化提供基础。

DESCRIPTION (provided by applicant): Hepatitis C virus (HCV) is now the most common cause of death in patients coinfected with the human immunodeficiency virus (HIV). In the U.S., 1/3 of all HIV-infected patients are coinfected with HCV. HIV/HCV coinfection has been associated with rapid progression of liver fibrosis, cirrhosis, and hepatic failure. Thus, HCV therapy is critical for long-term survival of HIV/HCV-coinfected patients. However, -70% of HIV/HCV patients have been reported to develop severe weight loss during treatment of HCV, and this can result in premature cessation or modification of HCV therapy. Since this adverse effect can prevent patients at high- risk of advanced liver disease from receiving optimal therapy, determination of the incidence and degree of weight loss among HIV/HCV patients receiving dual HIV/HCV therapy is needed. Studies that also elucidate risk factors for weight loss can enhance understanding of biological mechanisms behind it. This retrospective cohort study seeks to examine the incidence of weight loss in dually treated HIV/HCV patients compared to 1) HCV-monoinfected patients who receive HCV therapy and 2) HIV-monoinfected individuals receiving only HIV therapy. Risk factors for weight loss will also be examined. The results of this epidemiological study may ultimately help to allow optimal treatment of HCV in HIV/HCV patients and provide the foundation to evaluate changes in body composition and metabolic abnormalities accompanying weight loss.