Micropower Potentiostat for Implantable Glucose Sensors

描述（由申请人提供）： 需要开发用于连续监测糖尿病中的葡萄糖的可植入传感器。我们以前开发了一种植入式葡萄糖传感器的基础上固定葡萄糖氧化酶耦合到一个氧电极，并采用该传感器作为静脉植入超过100天的狗没有重新校准。我们现在已经开发了一种新的基于组织的传感器设计，可应用于广泛的糖尿病人群，但进一步的开发需要目前无法获得的专用电子电路。拟议的项目是一个第二阶段的努力，以完成新的微功率恒电位仪仪器的开发，主要用于植入式葡萄糖传感器，但也可能发现与其他植入式传感器和设备的应用。在第一阶段，我们开始开发传感器长期运行所需的超低功耗恒电位仪电路，并成功证明了独特的新型集成恒电位仪电路设计的可行性。同时，我们也在开发传感器本身，以及必要的密封平台，以容纳仪器并将传感器输送到植入部位。有了这些其他所需的元素，现在可以开始电子开发项目的第二阶段，并完成长期植入式葡萄糖传感器系统的关键元素。

DESCRIPTION (provided by applicant): There is a need for development of implantable sensors for continuous monitoring of glucose in diabetes. We previously developed an implantable glucose sensor based on immobilized glucose oxidase coupled to an oxygen electrode and employed the sensor as an intravenous implant for over 100 days in dogs without recalibration. We have now developed a new tissue-based sensor design for potential application to a broad portion of the diabetic population, but further development requires specialized electronic circuitry not currently available. The proposed project is a Phase II effort to complete the development of novel micropower potentiostat instrumentation, principally for the implantable glucose sensor, but that may also find application with other implantable sensors and devices. In Phase I, we initiated development of the ultra-low power potentiostat circuitry needed for long-term operation of the sensor, and successfully demonstrated the feasibility of a unique, new integrated potentiostat circuit design. In parallel efforts, we have been developing the sensor itself, as well as the necessary hermetically sealed platform to contain the instrumentation and deliver the sensor to the implant site. With these other required elements in hand, it is now appropriate to initiate Phase II of the electronics development project and complete this key element of the long-term implantable glucose sensor system.