Interventions for Financially Disadvantaged Mothers

本申请为中期职业研究者奖在以患者为导向的研究（K-24） 要求支持候选人增加对初级临床研究者的指导，并加强其以患者为导向的研究。这项研究的重点是对经济上处于不利地位的母亲的干预，因为这些妇女患情绪和焦虑症的风险很高，特别是与人际暴力有关的疾病，如创伤后应激障碍（PTSD）和重度抑郁症。尽管创伤后应激障碍和重度抑郁症相关的痛苦和明显的损害，很少有干预措施进行了系统的测试，包括FD妇女与这些疾病，因为因素，如工具性障碍（例如，儿童保育、运输）、怀孕或哺乳使这些妇女无法参加临床试验或获得治疗。作为一名研究人员， 在妇女的心理健康，特别是创伤，创伤后应激障碍和严重抑郁症的广泛背景下，候选人建议继续和扩大她对这一研究不足，服务不足和弱势妇女群体的病人为导向的研究。该提案的主要目的是利用以患者为导向的研究中期职业调查员奖解放的时间，增加候选人对与她未来研究相关的几个领域的知识，并开发，评估和传播有关FD母亲干预措施的新信息。到 为此，职业发展计划增加了候选人在以下方面的经验，知识和技能：1）儿童和母婴互动评估培训和父母干预培训。2)统计、干预研究设计和方法以及成本问题。职业发展计划还建议：1）扩大候选人对初级调查员的指导，目的是吸引他们从事以病人为导向的研究，2）通过教育专业人员、立法者和公众，提高对FD妇女生活中心理健康障碍和人际暴力的认识。该应用程序的研究计划侧重于两个正在进行的R-21研究FD妇女的干预措施，正在进行的研究，待定的研究，并提出了FD母亲的干预研究。总之，该奖项将为候选人的职业发展，指导，以及正在进行的和新的以患者为导向的研究高风险和研究不足的妇女群体提供关键支持。

This application for a Mid-Career Investigator Award in Patient-Oriented Research (K-24) requests support for the candidate to increase mentoring of beginning clinical investigators and enhance her patient-oriented research. This research focuses on interventions for financially-disadvantage (FD) mothers because these women are at high risk for mood and anxiety disorders, in particular, disorders related to interpersonal violence, such as posttraumatic stress disorder (PTSD) and major depression. Despite the distress and marked impairment associated with PTSD and major depression, few interventions have been systematically tested that include FD women with these disorders, because factors, such as instrumental barriers (e.g., child care, transport), pregnancy, or breastfeeding have excluded these women from participation in clinical trials or access to treatment. As a researcher with an extensive background in the mental health of women, in particular trauma, PTSD, and major depression, the candidate proposes to continue and expand her patient-oriented research on this understudied, underserved, and vulnerable group of women. The chief aim of this proposal is to use time liberated by the Mid-Career Investigator Award in Patient-Oriented Research to increase the candidate's knowledge of several areas relevant to her future research and to develop, evaluate and disseminate new information on interventions for FD mothers. To this end, the career development plan increases the candidate's experience, knowledge, and skills in the following areas: 1) Child and maternal-infant interaction assessment training and parent intervention training. 2) Statistics, intervention study design and methodology, and cost issues. The career development plan also proposes to 1) expand the candidate's mentoring of beginning investigators with the goal of attracting them to a career in patient-oriented research, and 2) increase awareness of mental health disorders and interpersonal violence in the lives of FD women by educating professionals, legislators, and the public. This application's research plan focuses on two ongoing R-21 studies of interventions with FD women, ongoing research, pending research, and proposed intervention research with FD mothers. In summary, this award would provide critical support for the candidate's career development, mentoring, and ongoing and new patient-oriented research on a high-risk and understudied group of women.