Exploiting messenger RNA export as a novel therapeutic strategy to treat cancer

癌症的新疗法代表了未满足的临床需求领域。我们已经确定了一种与癌症有关的新的生物学途径，即选择性mRNA输出。抑制基因表达途径的其他步骤的化合物是有希望的癌症治疗候选物，但mRNA输出抑制剂不存在。我们建议开发一流的mRNA输出抑制剂，选择性靶向RNA加工失调的转录成瘾性癌症。

Novel therapies for cancers represent an area of unmet clinical need. We have identified a new biological pathway implicated in cancer, namely selective mRNA export. Compounds inhibiting other steps of the gene expression pathway are promising therapeutic candidates for cancer, yet mRNA export inhibitors do not exist. We propose to develop first-in-class inhibitors of mRNA export that selectively target transcriptionally addicted cancers with dysregulated RNA processing.