The efficacy of a leucine-enriched whey protein for improving muscle health in older adults

到明年，20%的英国人口将超过65岁，这将大大增加对健康和社会保健的压力。肌肉质量是健康老龄化和长寿的强有力预测因素，其维持通过肌肉蛋白质合成（MPS）和分解（MPB）之间的动态平衡来控制。我们知道，衰老与肌肉质量和功能的逐渐丧失有关，这是由于一种称为肌肉减少症的复杂的早期疾病，这种疾病始于中年;然而，这种疾病的全部潜在病因尚不清楚。一个已知的促成肌肉减少症发展的因素是骨骼肌的“合成代谢阻力”，随着年龄的增长，老年肌肉不能像年轻时那样对关键的合成代谢刺激（即氨基酸营养和收缩活动）产生相同的合成代谢或“维持”反应。考虑到预防或减轻肌肉减少症的策略对健康和社会的巨大潜在影响，作为UoN，UoB和AFI之间的合资企业，该研究项目将旨在确定一种新型蛋白质补充剂克服合成代谢抵抗的功效，作为一种独立的策略和阻力运动训练的辅助手段。

By as soon as next year, 20% of the UK population will be over the age of 65-years, dramatically increasing pressures upon health and social care. Muscle mass is a strong predictor of healthy ageing and longevity, with maintenance of this controlled via a dynamic equilibrium between muscle protein synthesis (MPS) and breakdown (MPB). We know that ageing is associated with a progressive loss of muscle mass and function due to a complex, incipient disease known as sarcopenia which begins mid-life; however, the full underlying aetiology of this condition is not yet known. One known contributor to the development of sarcopenia is the "anabolic resistance" of skeletal muscle with advancing chronological age, whereby older muscle is not able to mount the same anabolic, or "maintenance" responses to key anabolic stimuli (namely amino acid nutrition and contractile activity) as in youth. Given the large potential health and societal impact of strategies to prevent or attenuate sarcopenia, this studentship, as a joint venture between the UoN, UoB and AFI, will aim to determine the efficacy of a novel protein supplement for overcoming anabolic resistance, as both a stand-alone strategy and as an adjuvant to resistance exercise training