Role of cytidine deaminase in (epi)genetic adaptation of the plant immune system

作为无根生物，植物是适应环境压力的大师。汤恩实验室最近的研究表明，植物利用表观遗传机制，使它们的免疫系统长期抵御潜在的病虫害。本博士项目将研究模式植物拟南芥（Arabidopsis thaliana）抗性基因表达和多样化的表观遗传和遗传机制之间的相互作用。特别是，该项目将重点关注拟南芥胞苷脱氨酶CDA1在表观遗传标记调控中的作用及其对遗传多样性的影响。该学生将使用最先进的遗传和分子技术，并在一个高度动态的实验室工作，将基础研究与转化研究相结合，开发有利于可持续作物保护的新技术。

As sessile organisms, plants are masters in adapting to environmental stresses. Recent work from the Ton lab has shown that plants employ epigenetic mechanisms to prime their immune system long-term against potential pests and diseases. This PhD project will study the interplay between epigenetic and genetic mechanisms controlling expression and diversification of resistance (R) genes in the model plant species Arabidopsis thaliana. In particular, the project will focus on the role of the Arabidopsis cytidine deaminase CDA1 in the modulation of epigenetic marks and its impact on genetic diversity. The student will use state-of-the art genetic and molecular techniques, and work in a highly dynamic lab that combines fundamental research with translational research to develop new technologies that benefit sustainable crop protection.