Exploring the role of nitrogen metabolism, energy metabolism and mitochondrial function in the pathophysiological mechanisms of paediatric ME/CFS.

肌痛性脑脊髓炎/慢性疲劳综合征（ME/CFS）是一种通过症状诊断的疾病。我们的广泛研究导致了一种假设，即ME/CFS是由细胞中能量生产的有毒副产物引起的。这个问题可以由许多独特的方式引起，这可以解释ME/CFS患者群体的多样性。我们建议用一种新颖的个性化实验设计来检验这一假设，同时为ME/CFS领域提供大量的新知识。

Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a disease diagnosed by symptoms. Our extensive research has led to a hypothesis that ME/CFS results from toxic by-products of energy production in their cells. This problem can be caused by many unique ways, which could explain the diversity of the ME/CFS patient population. We propose to test this hypothesis with a novel personalised experimental design to simultaneously produce a plethora of new knowledge for the field of ME/CFS.