Development of a Telemetric Monitor for IOP

描述（由申请人提供）：本提案的目的是开发和实施遥测IOP监测系统，该系统可用于在长时间内获得连续的全天候IOP数据。遥测24小时IOP表征很重要，原因有二。首先，它将为研究个体视神经乳头对IOP的敏感性的实验、计算和理论研究奠定基础。其次，为青光眼患者的遥测眼压监测和临床实现真正的24小时眼压控制奠定了基础。 具体目标和目的是：1）开发遥测IOP监测仪; 2）开发可视化和表征遥测24小时IOP数据所需的软件; 3）使用具体目标1和2中开发的硬件和软件捕获和表征6个月期间的24小时IOP数据。 该方法包括通过将传感器集成到LSD设计的眼外巩膜固定硅胶基板（通过硅胶管连接到前房）中，对现有的经验证设计的皮下电池供电植入式压力监测器（DISS T-27-F系列植入体）进行修改。与DISS系统相关的硬件和软件将专门针对24小时IOP数据的采集、可视化和定量进行优化。将在软件中开发和实施用于可视化和量化眼睛随时间暴露的IOP水平的自定义自动算法。将表征系统准确捕获昼夜IOP波动模式（幅度、频率和持续时间）的能力，以及其准确记录短期IOP波动（如眨眼和擦眼）的能力。 目标是为长期（至少12个月）、24小时遥测IOP监测提供成熟的交钥匙解决方案。这样的系统将推进青光眼研究，并对IOP在青光眼性视神经病变的发展和进展中的作用产生有价值的见解。

DESCRIPTION (provided by applicant): The purpose of the present proposal is to develop and implement a telemetric IOP monitoring system that can be used to obtain continuous, round-the-clock IOP data over long periods of time. Telemetric 24-hour IOP characterization is important for two reasons. First, it will lay the foundation for experimental, computational, and theoretical studies to investigate individual optic nerve head susceptibility to IOP. Second, it will lay the foundation for telemetric IOP monitoring of glaucoma patients and the clinical achievement of true, 24-hour intraocular pressure control. The Specific Aims and Objectives are 1) to develop a telemetric IOP monitor; 2) to develop the software necessary to visualize and characterize telemetric 24-hour IOP data; and 3) to use the hardware and software developed in Specific Aims 1 and 2 to capture and characterize 24-hour IOP data over a 6-month period. The Methodology includes modifying an existing subcutaneous, battery-powered, implantable pressure monitor of proven design (DISS T-27-F series implant) by integrating the transducer into an LSD-designed, extraocular, sclera-fixated, silicone baseplate that is connected to the anterior chamber via a silicone tube. Hardware and software associated with the DISS system will be specifically optimized for the capture, visualization, and quantification of 24-hour IOP data. Custom, automated algorithms for visualizing and quantifying the IOP levels to which the eye is exposed over time will be developed and implemented in software. The system's ability to accurately capture the pattern of diurnal IOP fluctuation (magnitude, frequency, and duration) will be characterized, as will its ability to accurately record short-term IOP fluctuations as in the case of blink and eye rub. The goal is to provide a mature, turnkey solution for long-term (minimum 12 month), 24-hour, telemetric IOP monitoring. Such a system will advance glaucoma research and yield valuable insight into the role of IOP in the development and progression of glaucomatous optic neuropathy.