Molecular and Chemical Pharmacology Training Grant

描述（由申请人提供）：本申请支持化学和分子药理学培训计划，代表了斯坦福大学分子药理学系为应对过去十年来分子和结构生物学的异常快速发展而开展的一项新事业。虽然该部门在过去的几十年里有一个非常成功的研究生课程-它的几个毕业生现在可以在学术机构和行业的领导地位中找到-最近在生物科学知识的爆炸性增长已经清楚地表明，一套新的概念和技能将需要在未来的药理学成功的职业生涯。整个基因组的测序和无数蛋白质和信号转导途径的初步表征正在定义未来的药理学：研究复杂和微妙平衡的细胞调控网络，以及药物如何影响它们。为了使这一未来充分实现，将需要应用严格的定量方法和概念-物理学、化学、系统分析和信息学的方法和概念。因此，它还需要吸引不同类型的学生到该领域，一个学生的兴趣和能力在定量科学。如果药理学学科要迎接这一挑战，它必须制定研究生培训计划，预测和传达从目前阶段推进该领域所需的知识。基于其强大的创新传统，斯坦福大学分子药理学系正在实施双轨研究生课程。第一个轨道强调分子生物学，细胞生物学和医学药理学，认识到建立分子生物学方法仍然有很大的希望发现和分析生命的过程。第二个轨道更加强调严格的定量分析方法，认识到这是解决下一代问题所需的分析类型，并履行药理学作为与药物作用机制有关的科学的使命。

DESCRIPTION (provided by applicant): The present application for support of the Chemical and Molecular Pharmacology Training Program represents a new venture undertaken by the Stanford Department of Molecular Pharmacology in response to the extraordinarily rapid advances in molecular and structural biology over the past ten years. While the Department has had a very successful graduate program over the past decades--several of its graduates can now be found in leading positions in academic institutions and in industry--the recent explosive growth of knowledge in biological sciences has made it clear that a new set of concepts and skills will be needed for a successful career in Pharmacology in the future. The sequencing of whole genomes and the initial characterization of myriad proteins and signal transduction pathways is defining the pharmacology of the future: the study of intricate and delicately-balanced cell regulatory networks, and of how drugs can and do impinge upon them. To fully bring this future to fruition will require the application of rigorous quantitative methods and concepts--those of physics, chemistry, systems analysis and informatics. It will therefore also require the attracting of a different type of student to the field, a student with interests and abilities in quantitative science. If the discipline of Pharmacology is to meet this challenge, it must develop graduate training programs that anticipate and convey the knowledge required to advance the field from its present stage. Building on its strong tradition of innovation the Stanford Department of Molecular Pharmacology is therefore implementing a two-track graduate program. The first track emphasizes molecular biology, cell biology, and medical pharmacology, in recognition of the fact that established molecular biological methods still hold a great deal of promise for discovery and analysis of life's processes. The second track places greater emphasis on rigorous quantitative methods of analysis, in recognition of the fact that this is the type of analysis required to solve the next generation of problems and fulfill the mission of Pharmacology as the science concerned with mechanisms of drug action.