Training Grant in Dynamic Aspects of Chemical Biology

描述(申请人提供)：本申请请求继续支持堪萨斯大学化学系、药物化学系和分子生物科学系化学生物学动态方面的博士培训计划。该培训计划旨在培养具有生物信息和技能工作水平的化学科学博士毕业生，以及掌握化学信息和技能的生物科学博士毕业生。堪萨斯大学的这个项目利用了当地50多年来科学家在化学、生物和制药科学领域密切而有效的合作的传统。导师将从参与的系中选出：11.5名化学教员，6.5名分子生物科学教员，6名药物化学教员，1名药理学和毒理学教员(0.5表示一名教职员工同时担任药物化学和化学专业)。请求为7名受训人员提供支助，比上次提交的增加了1人。学员完成一项计划，其特点是在已有优势的领域进行集中的博士教育和研究；课程课程将学员的信息和技能扩展到部门边界以外的领域；研究轮换，使学员在项目的所有领域都有个人研究经验；参加特别研讨会和年度研讨会的组织和演示。受训者的博士研究项目分为三个领域之一：(1)生物相关分子的合成；(2)生物物理结构分析；(3)酶机制和生物分子动力学。培训资助课程从生物信息学和/或分子建模的核心课程开始，还有一门课程--科学诚信问题。然后，每个化学和药物化学学生被要求至少选修一门分子生物科学课程，反之亦然。此外，受训人员符合本国部门的所有博士要求。所有受训人员都要进行两次研究轮换。学员管理和参与年度培训资助研讨会，并邀请演讲者参加化学生物学研讨会。

DESCRIPTION (provided by applicant): This application requests continued support for the doctoral training program in Dynamic Aspects of Chemical Biology in the Departments of Chemistry, Medicinal Chemistry, and Molecular Biosciences at the University of Kansas. This training program aims to educate doctoral graduates in the chemical sciences who will have a working level of biological information and skills, and doctoral graduates in the biological sciences who will have a command of chemical information and skills. The program at the University of Kansas takes advantage of a local tradition of over 50 years of close and effective collaboration among scientists at the interface of chemistry, biology, and the pharmaceutical sciences. Mentors will be drawn from the participating departments: 11.5 faculty members from Chemistry, 6.5 from Molecular Biosciences, 6 from Medicinal Chemistry, and 1 from Pharmacology and Toxicology (the 0.5 reflects a faculty member with joint appointments in Medicinal Chemistry and Chemistry). Support is requested for seven trainees, an increase of one from the previous submission. Trainees complete a program that features focused doctoral education and research in an area of established strength; a curriculum of courses that broadens the information and skills of trainees into areas beyond departmental boundaries; research rotations that give trainees personal research experience in all areas of the program; and participation in both organization of and presentation at special seminars and an annual symposium. The doctoral research projects of trainees fall into one of three areas: (1) synthesis of molecules of biological relevance; (2) biophysical structure analysis; (3) enzyme mechanisms and biomolecular dynamics. The training-grant curriculum begins with core courses in bioinformatics and/or molecular modeling, along with a course, Issues in Scientific Integrity. Then each chemistry and medicinal chemistry student is required to take at least one elective course in molecular biosciences and vice versa. In addition, trainees meet all doctoral requirements of their home departments. All trainees carry out two research rotations. Trainees manage and participate in the Annual Training Grant Symposium as well as in inviting speakers for a Chemical Biology seminar.