Kinetics and Mechanism of Pd(II) X-OH Anion Metathesis in the Suzuki-Miyaura Reaction

钯催化的交叉偶联反应在合成化学中非常重要。具体来说，Suzuki-Miyaura反应是最广泛使用的C-C键形成过程之一，通常用于制药和农业化学合成，规模从小(Mmol)到大(吨)。在Suzuki-Miyaura反应中，经常会遇到Ar-X还原、原脱溴等副反应。这些有害的反应可能会消耗宝贵的起始原料，阻碍生产性催化剂的周转，并使提纯变得复杂。本项目将加深对Suzuki-Miyaura反应中的一个关键机制事件的理解，并利用这些信息来尝试消除这些问题，并改进与药物和农用化学品相关的分子的合成。本项目旨在建立Suzuki-Miyaura反应的X-OH阴离子歧化事件的机理和动力学，并利用这些信息开发更好的催化剂。学生将接受动力学、机理、有机化学、有机金属化学、光谱学和合成方面的多种培训，并精通与工业相关的催化。

Palladium-catalysed cross-coupling is incredibly important in synthetic chemistry. The Suzuki-Miyaura reaction in particularis one of the most widely used C-C bond forming processes and is routinely employed in pharmaceutical and agrochemicalsynthesis on small (mmol) to large (tonne) scale. Side reactions such as Ar-X reduction and protodeboronation are oftenencountered in the Suzuki-Miyaura reaction. These unwanted reactions can consume valuable starting materials, impedeproductive catalyst turnover, and complicate purification. This project will develop an understanding of a key mechanisticevent in the Suzuki-Miyaura reaction and use this information to try to eliminate these problems and improve the synthesisof pharmaceutically- and agrochemical-relevant molecules.This project aims to establish the mechanism and kinetics of the X-OH anion metathesis event of the Suzuki-Miyaura reaction and use this information to develop better catalysis. The student will receive a diverse training in kinetics,mechanism, organic chemistry, organometallic chemistry, spectroscopy, and synthesis, as well as becoming well-versed inindustrially-relevant catalysis.