The effect of the nasopharyngeal host microbiome on the transcriptional host response during viral infection

目前对温病的管理、治疗和研究的做法是将感染分为细菌性感染和病毒性感染。然而，对于儿科呼吸道感染，将患者分为这两类仍然是一项诊断挑战。由于目前基于病原体的诊断金标准的局限性，细菌感染通常是通过发现强烈的炎症来诊断的，这是通过生物标志物c反应蛋白（CRP）或白细胞计数（WBC）的升高来注意到的。然而，很大比例的病毒感染患者，如流感和呼吸道合胞病毒（RSV），也显示出表明强烈炎症的生物标志物特征。在我的博士学位课程中，我想探索决定这些对病毒感染的不寻常的炎症免疫反应的因素。我的假设是，宿主对病毒感染的反应受到呼吸道微生物群中存在的细菌的影响。

The current practice for the management, treatment and research of febrile diseases is to separate infections into either bacterial or viral. However, for paediatric respiratory infections, separating patients into this binary remains a diagnostic challenge. Due to limitations of current gold standard, pathogen based diagnostics, bacterial infections are often diagnosed from the finding of intense inflammation, which is noted from raised levels of the biomarkers C-reactive protein (CRP) or white blood cell count (WBC). However, a high proportion of patients with viral infections, such as influenza and respiratory syncytial virus (RSV), also display biomarker signatures indicative of intense inflammation. For my PhD, I want to explore the factors determining these unusual inflammatory immune responses to viral infections. My hypothesis is that the host response to viral infections is influenced by the bacteria present in the respiratory microbiome.