Longitudinal Study--Sleep-Disordered Breathing/Pregnancy

描述（由申请人准备）：候选人的计划/培训： 以病人为导向的睡眠医学和流行病学研究。培训将 包括密切指导完成研究协议，先进的 流行病学课程工作，面向病人的研究， 睡眠医学和呼吸神经生物学。 环境：宾夕法尼亚大学是一个独特的适合环境 获得这个培训奖。睡眠和呼吸神经生物学中心 将在以病人为导向的研究中提供指导经验。中心 临床流行病学和生物统计学将提供先进的教学 训练 研究：在怀孕期间，生理变化，包括妊娠体重 可能使妇女面临更大的发展风险， 睡眠呼吸障碍（SDB）打鼾是睡眠呼吸障碍的常见症状， 是孕妇中常见的主诉，在习惯性B y中经历， 多达23%的女性在怀孕的最后三个月结束时。 女性打鼾者可能表现为睡眠呼吸障碍 大部分尚未被探索在一般人群中，基线肥胖和 体重增加都与睡眠障碍的风险增加有关 呼吸了这是我们的核心假设，怀孕是一个时间 加速发展的睡眠呼吸障碍的妇女，其中 在基线身体升高的女性中，增加的程度可能更大 体重指数（BMI）或更大的妊娠期体重增加。本方案检查 女性睡眠呼吸障碍事件的数量是否增加 以及基线体重状况和体重增加 影响SDB的程度。研究的具体目标 建议是：1）检验假设，呼吸紊乱指数 (RDI)，这是一种测量在呼吸道感染期间每小时异常呼吸事件数量的方法。 睡眠，在怀孕期间增加;并确定是否 肥胖妇女的增加程度更大; 2）确定具体的 影响具有临床意义的风险的临床特征 SDB的严重程度增加。

DESCRIPTION (prepared by applicant): Candidate's Plans/Training: The patient-oriented research in sleep medicine and epidemiology. Training will include closely mentored completion of the research protocol, advanced epidemiological course work in patient-oriented research advanced training in sleep medicine and respiratory neurobiology . Environment: The University of Pennsylvania is a uniquely suited environment for this training award. The Center for Sleep and Respiratory Neurobiology will provide a mentored experience in patient-oriented research. The Center for Clinical Epidemiology and Biostatistics will provide advanced didactic training. Research: During pregnancy, physiologic changes including gestational weight gain take place that may place women at increased risk for the development of sleep-disordered breathing (SDB). Snoring, which is a common symptom of SDB, is a frequent complaint among pregnant women, experienced on a habitual b y as many as 23 percent of women by the end of the final trimester of pregnancy. The possibility regnant women snorers may manifest sleep-disordered breathing has remained largely unexplored. In general population, baseline obesity and weight gain are both associated with an increased risk for sleep-disordered breathing. It is our central hypothesis that pregnancy is a time of accelerated development of sleep disordered breathing in women, in which the degree of increase is likely to be larger in women with elevated baseline body mass index (BMI) or greater gestational weight gain. This protocol examines whether the number of sleep-disordered breathing events increases in women over the course of pregnancy and how baseline weight status and weight gain during pregnancy impact the degree of SDB. The specific aims of the study proposal are: 1) to test the hypothesis that the respiratory disturbance index (RDI), a measure of the number of abnormal respiratory events hourly during sleep, increases over the course of pregnancy; and to determine whether the degree of increase is greater in obese women; and 2) to identify specific clinical characteristics that influence the risk for clinically significant increases in the severity of SDB.