Integration of polymeric 3D scaffolds within a perfused organ-on-a-chip system for the development of a soft organ model

生物材料的一个重要研究方向是实验室培养器官的发展，这些器官越来越多地模仿人体器官的结构和生物复杂性。这些器官芯片（OOAC/微生理系统）正日益发展成为药物试验中动物实验的替代方法。ooac领域目前正在超越学术研究，许多公司目前正在成为该领域的主要参与者。其中一家公司是CN-Bio，他们开发了一个完整的微生理OOAC系统，可以研究多器官的相互作用，并提供了一个标准化的基于芯片/板的系统来研究药物毒性等。在这个项目中，我们将与CN-Bio合作开发3D细胞培养的聚合物支架，并将其纳入CNBio灌注系统。我们将开发柔软和灵活的聚合物系统，目标是在器官芯片系统中开发软器官模型。这些体外模型将用于探索健康和病变组织模型。例如，我们的目标是探索炎症和癌症组织模型。如果成功，该设备将填补一个重要的未满足的需求，作为一个多面器官模型/体外测试平台。

An important research strand in biomaterials is the development of in-lab grown organs, which are increasingly mimicking the structural and biological complexity of human organs. These organs-on-a-chip (OOAC/microphysiological systems) are increasingly developed as an alternative to the use of animals in pharmaceutical testing. The field of OOACs is currently emerging beyond academic research and a number of companies are currently establishing themselves as key players in the field. One of these companies is CN-Bio, who have developed a complete microphysiological OOAC system that can investigate multi-organ interactions, and provide a standardised chip/plate based system to investigate drug toxicity and more. In this project we will collaborate with CN-Bio to develop polymeric scaffolds enabling 3D cell culture and incorporate these into the CNBio perfusion system. We will develop soft and flexible polymeric systems to target the development of soft organ models within an organ-on-a-chip systems. These in vitro models will be used to explore healthy and diseased tissue models. For example, we could aim to explore inflamed and cancer tissue models. If successful, this device will fill an important unmet need as a multifaceted organ model/in vitro testing platform.